丹红注射液对血栓性浅静脉炎血液流变学、炎症细胞因子及内皮功能的影响  

Effect of Danhong Injection on Blood Rheology,Inflammatory Cytokines and Endothelial Function in Patients with Thrombotic Shallow Phlebitis

作　　者：李建鹏[1] 王峥[2] 

机构地区：[1]河南省中医院,郑州450002 [2]河南中医学院第一附属医院,郑州450000

出　　处：《中国实验方剂学杂志》2016年第3期192-196,共5页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:观察丹红注射液对血栓性浅静脉炎血液流变学、炎症细胞因子及内皮功能的影响。方法:随机将2014年2月至2015年1月在河南省中医院住院治疗的63例血栓性浅静脉炎患者分为两组,对照组给予阿司匹林肠溶片和低相对分子质量肝素钙注射液治疗,在对照组治疗的基础上,研究组给予丹红注射液治疗,治疗2周后,观察两组的疗效,并对比两组治疗前后的血流动力学、炎症指标、内皮功能变化情况。结果:1疗效:研究组的总有效率为92.86%,对照组的总有效率为76.19%,组间差异具有统计学意义(P<0.05)。2血液流变学:治疗后,两组的血浆黏度、全血高切还原黏度、全血低切还原黏度、血沉、红细胞聚集指数、红细胞变形指数、纤维蛋白均出现不同程度的下降,差异显著(P<0.05),且与对照组对比,研究组下降更加明显,差异显著(P<0.05)。3炎症细胞因子:治疗后,两组的白细胞介素-1(IL-1),IL-6,肿瘤坏死因子-α(TNF-α),高敏C-反应蛋白(hs-CRP)均出现显著性的下降(P<0.05),且研究组的IL-1,IL-6,TNF-α,hs-CRP均明显小于对照组(P<0.05)。4内皮功能:治疗后,两组的内皮素、血管性血友病因子均出现显著性的下降(P<0.05),且研究组的内皮素、血管性血友病因子均明显小于对照组的(P<0.05)。结论:丹红注射液能有效地改善血栓性浅静脉炎的临床症状,改善血流动力学情况和内皮功能,抑制炎症反应。Objective： To observe the effect of Danhong injection on blood rheology,inflammatory cytokines and endothelial function in patients with thrombotic shallow phlebitis. Method： Sixty-three patients with thrombotic shallow phlebitis hospitalized from February 2014 to January 2015 in our hospital were randomly divided into two groups. The patients in control group received aspirin enteric-coated metformin hydrochloride and low molecular weight heparin calcium injection treatment,on the basis of control group,the patients in research group also received Danhong injection for 2 weeks. Then the curative effect,hemodynamic changes,inflammation,and endothelial function before and after treatment of two groups were observed and compared. Result： 1 Curative effect： total effective rate in research group was 92. 86%,higher than 76. 19% in control group,with statistically significant difference between group（ P〈0. 05）. 2 Blood rheology： after treatment,blood plasma viscosity,whole blood high shear reductive viscosity,whole blood low shear reduction viscosity,blood sedimentation,erythrocyte aggregation index,erythrocyte deformation index,and fibrin had varying degrees of decline in two groups,with significant difference（ P〈0. 05）; and compared with the control group,the decline was more significant in research group,with significant difference（ P〈0. 05）. 3Inflammatory cytokines： after treatment,interleukin-1（ IL-1）,IL-6,tumor necrosis factor-α（ TNF-α）,high sensitive C-reaction protein（ hs-CRP） were reduced significantly in both groups（ P〈0. 05）,and the levels in research group were all significantly less than those in control group（ P〈0. 05）. 4 Endothelial function： after treatment,endothelin,and von willebrand factor were reduced significantly in bith groups（ P〈0. 05）,and the levels in research group were significantly less than those in control group（ P〈0. 05）. Conclusion： Danhong injection can effectively improve the clinical symptoms of thrombotic shal

关 键 词：血栓性浅静脉炎 血流动力学 炎症 内皮功能 

分 类 号：R287.6[医药卫生—中药学]