C-Kit^+心脏干细胞在心肌修复中的作用  

Action of C-Kit^+Cardiac Stem Cells in Myocardial Repairment

作　　者：龚剑萍[1] 刘剑[1] 

机构地区：[1]重庆医科大学附属第一医院心血管内科,重庆400016

出　　处：《心血管病学进展》2016年第1期62-65,共4页Advances in Cardiovascular Diseases

摘　　要：终末期冠心病是因大量心肌细胞丧失功能而致不可逆转性损害,以心力衰竭为主要表现的临床综合征。自发现C-Kit^+心脏干细胞可分化为心肌细胞后,移植C-Kit^+心脏干细胞促进心肌的修复便成为基础和临床研究的热点之一。尽管还有诸多问题尚待解决,但这为终末期心肌修复的研究带来新的方向。现就C-Kit受体及配体、C-Kit^+心脏干细胞及其在心肌修复中的作用、局限性做一综述。End-stage coronary heart disease is caused by the loss of function of myocardial cells in large quantities resuhing in direct irreversible damage and manifested into heart failure. As C-Kit^＋ cardiac stem cells （ C-Ki^＋ CSCs） have been reported to differentiate into myocardial cells,the basic and clinical research has focused on transplanting C-Kit^＋ CSCs to the myocardial lesions to promote the repair of myocardial cell. Although many problems remain unsolved, this focus has developed a new direction in the research of cardiac treatment. In this paper, we reviewed the C-Kit receptor and its ligand, C-Kit^＋ CSCs and their actions in myocardial repair as well as relevant limitations.

关 键 词：C-KIT受体 心脏干细胞 心肌修复 

分 类 号：R541.4[医药卫生—心血管疾病]