不同剂量维生素D对Roux-en-Y胃旁路减重术后骨代谢异常的影响  

Different doses vitamin D to bone metabolism in obese persons after Roux-en-Y gastric bypass

作　　者：祁庆姣 蔡鹏[1] 闫庆凯[1] 王旭开[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所心血管内科重庆市心血管病研究所,重庆400042 [2]重庆市酉阳县中医院内科,重庆409800

出　　处：《局解手术学杂志》2016年第2期116-119,共4页Journal of Regional Anatomy and Operative Surgery

基　　金：国家自然科学基金(81370367)

摘　　要：目的分析不同剂量维生素D补充对于Roux-en-Y胃旁路术(RYGB)术后6个月患者骨密度的影响。方法将36例RYGB术后患者随机分为对照组(13例)、低剂量组(11例)和高剂量组(12例),观察不同剂量维生素D(400 IU/d和1 600 IU/d)对患者术后6个月骨密度的影响并与对照组比较。结果术后6个月,入选研究对象体质量和身体质量指数(BMI)在术后6个月均明显下降,差异有统计学意义(P<0.05),其中1 600 IU/d的维生素D补充治疗可升高术后患者的血钙和25-羟基-维生素D(25-hydroxyvitamin D,25[OH]D),同时骨密度明显增加,差异有统计学意义(P<0.05)。结论 1 600 IU/d的维生素D补充治疗对于PYGB术后的骨密度降低具有改善作用。Objective To determine the effect of different doses vitamin D supplementation to the change of bone metabolism in 6months after Roux-en-Y gastric bypass（ RYGB）. Methods The change of body weight and body mass index（ BMI） in 36 patients in 6months after RYGB WAS analyzed. Then,the effect of low-dose（ n = 11,400 IU / day） and high-dose（ n = 12,1 600 IU / day） vitamin D to the serum calcium,25-hydroxyvitamin D and bone density were observed,and 15 patients as control. Results In 6 months after RYGB,the body weight and BMI were decreased,and the differences were statistical significance（ P 〈 0. 05）. The serum calcium,25-hydroxyvitamin D and bone density were increased in high-dose group,and the differences were statistical significance（ P 〈 0. 05）. Conclusion High-dose（ 1 600 IU/day） vitamin D supplementation is effective to the bone loss of patients undergoing RYGB.

关 键 词：胃旁路术 肥胖 骨代谢 维生素D 

分 类 号：R587.2[医药卫生—内分泌]