一步法工艺合成3,5,6-三氯吡啶-2-醇钠  

One-step for Synthesis of 3,5,6-Trichloropyridin-2-ol

作　　者：王红伟 张璐 强金凤 方红新 梁锡臣 

机构地区：[1]安徽国星生物化学有限公司,安徽马鞍山243000

出　　处：《安徽化工》2016年第1期56-59,共4页Anhui Chemical Industry

摘　　要：以CuCl_2复合催化剂催化三氯乙酰氯和丙烯腈制得三氯吡啶醇钠,不需要溶剂,将加成反应和环合反应并为一步来制得三氯吡啶醇钠。实验考查了反应温度、反应时间、催化剂等因素对合成收率的影响。此方法合成工艺简单,节约成本,三氯吡啶醇钠的收率提高到80%。The article describes that the CuC12 complex catalysts is used to synthesis sodium 3,5,6-trichloropyridin-2-olate as a raw material in trichloroacetyl chloride and acrylonitrile. The reaction solvent is not necessary and addition reaction and cyclization are into one step. Experiment examined the factors of yield such as temperature, reaction time and the catalyst. This method of synthesis process is simple, cost-effective and the yield of sodium 3,5,6-trichloropyridin-2-olate increased to 80%.

关 键 词：3 5 6-三氯吡啶-2-醇钠 三氯乙酰氯 丙烯腈 一步法 

分 类 号：TQ253[化学工程—有机化工] S482.33[农业科学—农药学]