含银微纳米复合材料在生物医学应用的研究进展  

Current Status and Development of Biomedical Nanosilver-contained Composites

作　　者：丁琪[1] 李明熹[1] 杨芳[1,2] 顾宁[1,2] 

机构地区：[1]东南大学生物科学与医学工程学院江苏省生物材料与器件重点实验室生物电子学国家重点实验室,江苏南京210096 [2]苏州纳米科技协同创新中心纳米药物与生物材料专业中心,江苏苏州221009

出　　处：《中国材料进展》2016年第1期10-16,48,共7页Materials China

基　　金：国家重大科学研究计划项目(2011CB933503);苏州市纳米科技专项(ZXG2012016)

摘　　要：近些年来,微纳米复合材料发展十分迅速。微纳米复合材料通常由两种或以上的不同材料组成在一个单元结构里,藉此具有多功能的、功能增强或协同增强的特性。含银微纳米复合材料是其中重要的研究分支,在当前生物医学应用中取得了众多的功能集成或功能增强等研究成果。主要综述了银/聚合物和银/氧化铁两类微纳复合材料,首先总结了银/聚合物和银/氧化铁微纳复合材料的制备方法,包括乳液聚合法、原位生成/还原法、空穴法、离子交换法、一锅法、种子法、静电作用法以及胶束法等;其次,总结了银/聚合物和银/氧化铁复合材料在表面增强拉曼散射、光学成像、抗菌抗癌、免疫检测、电化学检测、催化降解等生物医学领域的应用,以及对未来发展趋势的展望。In recent years, microor nano-composite materials have been rapidly developed. Usually, composite materials are composed of two or more different agents in one micro- or nano-unit structure, which realizes the characteristics of multifunction or synergistic functions enhancement. Silver nanoparticle containing micro- or nano-composite materials are one of the most important research branches in the field of biomedical applications. In this review, firstly, the preparation methods of silver/polymer and silver/iron oxide composites were summarized, which include emulsion polymerization method, in-si- tu formation/reduction method, hole method, ion exchange method, one pot method, seed method, electrostatic interaction method as well as micelle method. Then, their applications have been reviewed. The promising applications on surface enhanced raman scattering, optical imaging, antibacterial, immune detection, electrochemical detection, catalytic degradation and so on have been described in detail.

关 键 词：银/聚合物微纳米复合材料 银/氧化铁微纳米复合材料 生物医学应用 

分 类 号：R114[医药卫生—卫生毒理学]