β-环糊精及其衍生物对烯酰吗啉的包合作用  

Inclusion Complexes of Dimethomorph withβ-Cyclodextrin and Its Derivatives

作　　者：李姝静[1] 周自若 张小军 

机构地区：[1]北京工商大学理学院化学系,北京100048 [2]中农立华生物科技股份有限公司,北京100052

出　　处：《农药》2016年第2期104-107,共4页Agrochemicals

基　　金：国家自然科学基金(21301012);北京市自然科学基金资助项目(2144047);教师队伍建设-青年英才计划YETP1444;教育部留学回国人员科研启动基金资助项目

摘　　要：[目的]研究β-环糊精及其衍生物对烯酰吗啉的包合作用。[方法]以β-环糊精(β-CD)、羟丙基-β-环糊精(HP-β-CD)、甲基-β-环糊精(Me-β-CD)为主体,制备烯酰吗啉的包合物,通过粉末X射线衍射、热重分析、差示扫描量热法等方法研究环糊精与烯酰吗啉的主客体作用。[结果]β-CD、HP-β-CD及Me-β-CD与烯酰吗啉形成了包合比1∶1的包合物,包合常数分别为910、749、1211 M-1。烯酰吗啉在水中的溶解度及稳定性均得到提高。[结论]研究结果将拓宽烯酰吗啉剂型的开发和应用方向。[Aims] The inclusion complexes of dimethomorph with β-cyclodextrin and its derivatives were investigated.[Methods] The inclusion complexes contain dimethomorph and β-cyclodextrin（β-CD）,（2-hydroxy）propyl-β-cyclodextrin（HP-β-CD）, methylated-β-cyclodextrin（Me-β-CD） were prepared by freeze-drying method. The effects of inclusion behavior of dimethomorph with β-CD, HP-β-CD, and Me-β-CD were investigated by X-ray diffraction（XRD）,thermogravimetric analysis（TG）, differential scanning calorimetry（DSC） and scanning electron microscopy（SEM）.[Results] The results showed that dimethomorph formed 1∶1 stoichiometric inclusion complex with β-CD, HP-β-CD and Me-β-CD. The apparent stability constant of dimethomorph with β-CD, HP-β-CD and Me-β-CD were 910, 749 and 1211 M-1, respectively. Additionally, the solubility and decomposition temperature of dimethomorph were increased. [Conclusions] Therefore, it can be a potentially promising way to promote its agrochemicals.

关 键 词：烯酰吗啉 环糊精 包合物 溶解性 

分 类 号：TQ455.4[化学工程—农药化工]