新诊断2型糖尿病患者尿VEGF水平及其相关因素分析  

Urinary VEGF level and its Related Factors in Newly Diagnosed Type 2 Diabetes Meillitus

作　　者：孟晓军[1] 孙莹[1] 罗雪梅[2] 曾映娟[2] 孙辽[1] 沙永红[2] 龙伟[2] 

机构地区：[1]中山大学附属第五医院内分泌科,广东珠海519000 [2]湖南吉首大学医学院,湖南吉首416000

出　　处：《医学临床研究》2016年第1期19-21,25,共4页Journal of Clinical Research

摘　　要：【目的】探讨新诊断2型糖尿病患者尿血管内皮生长因子（VEGF）水平及其影响因素。【方法】选取新诊断2型糖尿病患者73例，采用酶联免疫吸附法（ELISA）检测其尿中VEGF水平，按尿微量白蛋白分为正常蛋白尿（n=41）和微量蛋白尿（n=32）两组，比较两组患者尿中VEGF水平，采用相关和线性回归分析法分析患者尿中VEGF的影响因素。【结果】与正常蛋白尿组比较，微量白蛋白尿组的空腹血糖、糖化血红蛋白（HbA1c）、总胆固醇、低密度脂蛋白、血尿酸及尿VEGF水平均较高（P〈0．05）；患者尿VEGF与空腹血糖、HbA1c、总胆固醇、低密度脂蛋白、血尿酸和尿微量白蛋白成正相关；线性回归分析显示HbA1c和尿微量白蛋白是新诊断2型糖尿病患者尿VEGF的独立影响因素（Beta=18．4，0．626；P〈0．05）。【结论】新诊断2型糖尿病患者尿VEGF水平与HbA1c和尿微量白蛋白密切相关，可以作为新诊断2型糖尿病患者肾脏损伤的一个有效的评估指标之一。[Objective]To investigate urinary VEGF level and related factors in newly diagnosed type 2 diabetes mellitus （T2DM） patients. [Methods]The urinary VEGF level was measured by enzyme-linked immunosorbent assay （ELISA） in 71 patients with newly diagnosed T2DM. The urinary VEGF level and related biochemical indicators were compared between newly diagnosed T2DM patients with normal albuinuria （ n = 41） and microalbuminuria （ n = 32）. The related factors for the urinary VEGF level in newly diagnosed T2DM patients with analyzed by Pearson and Liner linear regression analysis. [Results]Compared with newly diagnosed T2DM patients with normal albuinuria, fasting blood glucose, glycated hemoglobin （HbA1c）, total cholesterol, low-density lipoprotein cholesterol, serum uric acid and urinary VEGF level were significantly higher in patients with microalbumin- uria. In newly diagnosed T2DM, the urinary VEGF level was positively related with fasting blood glucose, glycat- ed hemoglobin（HbAlc）, low-density lipoprotein cholesterol, serum uric acid and urine albuminuria. HbAle and urine albuminuria were independent factors for urinary VEGF level in newly diagnosed T2DM patients （Beta= 18.4,0.626; P =0.017,0.010 ）. [Conclusion]The urinary VEGF level is directly related with HbAlc and urine al- buminuria in newly diagnosed T2DM patients. The urinary VEGF level could be a potential marker for renal dam- age in newly diagnosed T2DM.

关 键 词：糖尿病 2型 血管内皮生长因子A/尿 糖尿病肾病 白蛋白尿 

分 类 号：R587.1[医药卫生—内分泌]