rhGM—CSF含漱液联合巴韦林气雾剂治疗儿童疱疹性咽峡炎疗效观察  

Clinical Performance of rhGM-CSF Gargles combined with Ribavirin Spray in the Treatment of Children with Herpetic Angina

作　　者：张鸿彦[1] 张国利[1] 赵文成[1] 孙禄[1] 徐燕霞[1] 

机构地区：[1]哈尔滨医科大学附属第一医院群力院区儿科,黑龙江哈尔滨150001

出　　处：《医学临床研究》2016年第1期26-27,32,共3页Journal of Clinical Research

基　　金：黑龙江省教育厅资助课题编号（11541182）

摘　　要：【目的】观察重组人粒细胞巨噬细胞刺激因子（rhGM—CSF）含漱液配合利巴韦林气雾剂对小儿口腔疱疹性咽峡炎的疗效。【方法】选取2013年5月至2014年3月于本院就诊的疱疹性咽峡炎患儿150例，随机分为两组，对照组使用利巴韦林气雾剂雾化，每天3次；观察组在对照组基础上联合rhGM-CSF含漱液，三餐后和睡前各1次，疗程1周。以症状改善、疱疹消失且无溃疡形成为治疗有效。比较两组患儿治疗的有效率以及症状改善时间和住院时长。【结果】疗程结束后，观察组总有效率（96％）明显高于对照组（84％），差异有统计学意义（P〈0．05）；观察组患儿疱疹消失时间、退热时间、住院时间均少于对照组，差异均具有统计学意义（P〈0．05）。【结论】rhGM-CSF含漱液联合利巴韦林气雾剂治疗小儿口腔疱疹性咽峡炎疗效肯定，且可迅速改善临床症状。[Objective]To investigate the clinical performance of rhGM-CSF Gargles combined with Ribavirin Spray in treatment of children with herpetic angina. [Methods]ISO children in our hospital from May 2013 to March 2014 with herpetic angina were chosen for this study in the First Clinical College affiliated to Harbin Medical University. The children were divided into two groups-the control group and the observation group. Both groups were treated with Ribavirin Spray after each meal and before sleep, but the observation group was treated with rhGM-CSF in addition to the Ribavirin spray. Success in this experiment was defined by three categories： clinical improvements, cure of herpes, and lack of ulceration. In addition, the two groups were compared with the efficiency, time to cure, and length of stay. [Results]The total success rate in the experimental group was 96%, which was significantly higher than the control group＇s with 84% success rate, the difference was statistically significant （ P〈0.05）. The time it took to cure herpes was 1.5 days shorter in experimental group than in control group, and the fever last time in experimental group was 8 hours less than in control group. The length of stay was 1 day shorter in the experimental group than the control group. The results are statistically significantly.[Conclusion]The clinical application of rhGM-CSF Gargles combined with Ribavirin Spray in treating pediatric oral herpes leads to a quicker and superior improvement in children with herpetic angina.

关 键 词：疱疹性咽峡炎/药物疗法 粒细胞巨噬细胞集落刺激因子 重组/投药和剂量 漱口药 利巴韦林/投药和剂量 气雾剂 

分 类 号：R766.12[医药卫生—耳鼻咽喉科]