2-氯-6-三氟甲基吡啶合成的新方法研究  

Preparation of 2-Chloro-6-trifluoromethylpyridines

作　　者：吴江[1] 周俊鹏[1] 石亚磊[1] 朱锦桃[1] 

机构地区：[1]浙江理工大学理学院,浙江杭州310018

出　　处：《化学试剂》2016年第2期163-168,共6页Chemical Reagents

摘　　要：研究了2-氯-6-三氟甲基吡啶的合成新方法。以三氟乙酸酐和巴豆酰氯为原料,经环合、氨化得到中间体2-羟基-6-三氟甲基吡啶,后者在苯膦酰二氯的催化下,经五氯化磷氯化有效地得到了2-氯-6-三氟甲基吡啶,总收率为41.6%。该制备路线原料廉价易得、反应条件温和、操作简单安全,有工业应用的前景。This work aims to establishe a new method of preparation of 2-chloro-6-trifluoromethylpyridines. 2-Hydroxy-6-trifluoromethylpyridines was obtained from trifluoroacetic anhydride and tigloyl chloride as starting material via ammonification. And then,2-chloro-6-trifluoromethylpyridines is prepared from 2-hydroxy-6-trifl-uoromethyl pyridines and phosphorus pentachloride under the catalysis of phenylphosphonic dichloride. The total yield is 41. 6%. Material is cheap and available for the new method which can run at moderate reaction conditions with simple and safe operation. And it has the prospect of industrial application.

关 键 词：巴豆酰氯 环合 苯膦酰二氯 2-氯-6-三氟甲基吡啶 催化氯化 合成 

分 类 号：O626[理学—有机化学]