9-乙基鸟嘌呤的合成  

Synthesis of 9-Ethylguanine

作　　者：王立中[1] 卞小琴[1] 冯琦[1] 徐志刚[1] 

机构地区：[1]泰州职业技术学院药学院,江苏泰州225300

出　　处：《化学试剂》2016年第2期189-192,共4页Chemical Reagents

基　　金：2014年江苏省自然科学基金"333工程"资助项目(BRA2014182);2013年江苏省高等学校大学生创新创业训练计划资助项目(201312106001Y);泰州职业技术学院重点科研资助项目(1828750KY1)

摘　　要：以丙二酸二乙酯、盐酸胍为起始原料,在碱性条件下缩合得到中间产物2-氨基-4,6-二羟基嘧啶,然后,以三乙胺为缚酸剂,在80℃下与三氯氧磷反应,再用氢氧化钠分解得到2-氨基-6-氯嘧啶-4(3H)-酮,然后经过乙氨基化、亚硝化、环合反应,得到最终反应产物。并通过优化反应条件,获得了最佳工艺参数。该反应路线操作简便、工艺路线可行。产物经过熔点、IR、~1HNMR、^(13)CNMR等表征确证。Starting from diethyl malonate and guanidine hydrochloride,condensation in basic conditions gave the intermediate2-amino-4,6-dihydroxypyrimidine. Then,in the presence of triethylamine as the acid-trpping agent and at a temperature of 80 ℃,2-amino-6-chloropyrimidin-4（ 3H）-one was prepared by an excess of phosphorus oxychloride and the decomposition of sodium hydroxide,and then after ethylamino,nitrosation and cyclization,obtain the target product. Though optimizing the reaction conditions,the optimal parameters are obtained. The reaction route is simple,feasible process routes. The product through the melting point,IR,1HNMR,13 CNMR were confirmed.

关 键 词：9-乙基鸟嘌呤 2-氨基-4 6-二羟基嘧啶 2-氨基-6-氯嘧啶-4(3H)-酮 2-氨基-6-乙胺基嘧啶-4(3H)-酮 

分 类 号：O629.74[理学—有机化学]