中国城市儿童性早熟现状的调查研究  

The status survey of children with precocious puberty in Chinese cities

作　　者：朱迪卿[1] 朱红[1] 

机构地区：[1]常州市第一人民医院儿保科,江苏常州213000

出　　处：《中国中西医结合儿科学》2016年第1期100-102,共3页Chinese Pediatrics of Integrated Traditional and Western Medicine

摘　　要：目的对国内城市儿童性早熟现状进行调查,为制定有效的预防策略,并推动儿童性早熟的临床规范化和个性化治疗提供理论依据。方法 2014年3月至12月在全国范围内开展"中国城市儿童性早熟现状调研"活动。调研共收集来自全国10余省市的2 687份问卷,其中1 714份问卷纳入统计分析。结果调查人群大多分布在全国10个主要省市,包括北京、上海、重庆、江苏、湖北等;调查患儿以女童为主,其男女比例约1∶16。诊断为中枢性性早熟的患者占75.79%(1 299/1 714);调查中初次诊断为中枢性性早熟患者占88.91%(1 524/1 714)。调查患者的骨龄为(10.00±1.77)岁,高于实际年龄(8.29±1.60)岁,差异有统计学意义(P<0.001);初次诊断为CPP的患者的骨龄为(10.11±1.70)岁,高于实际年龄(8.35±1.57)岁,差异均有统计学意义(P<0.001)。结论国内城市儿童性早熟就诊患者的年龄偏大,为防止患者就诊时已错过最佳的干预和治疗时机,应引起对疾病筛查的高度重视,做到早发现、早诊断和早治疗。Objective To investigate the status of patients with precocious puberty in Chinese cities, and provide a theoretical basis for making effective prevention strategy, and promoting clinical standardization and personalized treatment of precocious puberty. Methods ＂Precocious Puberty Research in Chinese cities＂ activities began in the period between March and December 2014. Among a total of 2 687 questionnaires, 1 714 were included in the final statistical analysis. Results The survey of patients with city distribution were mainly in 10 cities,the top three being Chongqing（ 21.28% ）, Changzhou （ 9. 26 % ） and Shanghai （ 8. 37 % ）. Girls dominated the survey, and male to female ratio was about 1 ： 16; In secondary inspection, patients diagnosed with central precocious puberty accounted for 75.79% by GnRH stimulation test. Initial diagnosis of patients with central precocious puberty accounted for 88.91%. In all patients with central precocious puberty, bone age was higher than the actual average age at about 1.65 years old and the differences were statistically significant（P〈0. 001）. Conclusion The patients with central precocious puberty in Chinese cities are generally older. In order to avoid missing the best time for intervention and treatment, great importance should be attached to the disease screening, and early detection, early diagnosis and early treatment must be done.

关 键 词：性早熟 性早熟年龄 中枢性性早熟 GnRH激发试验 儿童 

分 类 号：R195.2[医药卫生—卫生统计学]