卡托普利治疗有合并症的老年原发性高血压的效果  

Therapeutic effect of captopril on aged patients with essential hypertension and complications

作　　者：张旭媛[1] 叶睿[1] 刘震[1] 

机构地区：[1]广州医科大学附属市一人民医院心血管内科,广东广州510180

出　　处：《心血管康复医学杂志》2016年第1期81-84,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：广州市科技计划项目(2012Y2-00025)~~

摘　　要：目的:观察卡托普利治疗有合并症的老年原发性高血压的临床疗效,并评价其安全性。方法:选择我院收治的116例老年原发性高血压伴有脂代谢紊乱、糖尿病等合并症的患者,按照随机数字表法均分为阿替洛尔对照组和卡托普利组(在阿替洛尔对照组基础上加用卡托普利)。观察两组患者治疗前、后血压、心率、空腹血糖、血脂变化情况,评价其临床疗效和不良反应。结果:治疗后,卡托普利组总有效率明显高于阿替洛尔对照组(98.28%比87.93%,P<0.05);与阿替洛尔对照组比较,卡托普利组患者血压[(131.20±11.02/82.01±6.75)mmHg比(115.62±10.27/75.68±5.21)mmHg]、心率[(65.14±6.32)次/min比(57.21±4.02)次/min]、空腹血糖[(4.75±1.36)mmol比(3.65±1.24)mmol]、总胆固醇[(2.69±0.58)mmol/L比(2.10±0.41)mmol/L]、甘油三酯[(0.96±0.41)mmol/L比(0.72±0.35)mmol/L]、低密度脂蛋白胆固醇[(1.95±0.57)mmol/L比(1.71±0.40)mmol/L]水平降低更显著(P<0.05或<0.01);两组患者均未发生明显不良反应。结论:卡托普利治疗有合并症的老年原发性高血压的疗效比阿替洛尔更佳,且无不良反应,值得推广应用。Objective：To observe therapeutic effect of captopril treatment on aged patients with essential hypertension（EH）and complications and evaluate its safety.Methods：A total of 116 aged EH patients,who were complicated with dyslipidemia,diabetes mellitus etc.were selected from our hospital.According to random number table,they were randomly and equally divided into atenolol control group and captopril group（received captopril based on treatment of atenolol control group）.Blood pressure,heart rate,fasting plasma glucose（FPG）and blood lipids were observed and compared between two groups,the therapeutic effect and adverse reactions were assessed.Results：After treatment,total effective rate of captopril group was significantly higher than that of atenolol control group（98.28% vs.87.93%,P0.05）;compared with atenolol control group,there were significant reductions in levels of blood pressure[（131.20±11.02/82.01±6.75）mmHg vs.（115.62±10.27/75.68±5.21）mmHg],heart rate[（65.14±6.32）beats/min vs.（57.21±4.02）beats/min],FPG [（4.75±1.36）mmol vs.（3.65±1.24）mmol],total cholesterol[（2.69±0.58）mmol/L vs.（2.10±0.41）mmol/L],triglyceride[（0.96±0.41）mmol/L vs.（0.72±0.35）mmol/L]and low density lipoprotein cholesterol[（1.95±0.57）mmol/L vs.（1.71±0.40）mmol/L]in captopril group,P0.05or0.01.There were no obvious adverse reactions occurred in both groups.Conclusion：Compared with atenolol,captopril treatment possesses better therapeutic effect without adverse reactions in aged patients with essential hypertension and complications,which is worth extending.

关 键 词：老年人 高血压 卡托普利 阿替洛尔 

分 类 号：R544.1[医药卫生—心血管疾病]