单纯性超重和肥胖人群血清胎球蛋白A水平的变化  

Serum alpha2-Heremans-Schmid glycoprotein levels in subjects with simple overweight and obesity

作　　者：周中卫[1] 居会祥[1] 孙明忠[1] 丁福万[2] 江冬梅[2] 季禹乔[1] 季建伟[1] 

机构地区：[1]东南大学医学院附属盐城医院检验科,224001 [2]东南大学医学院附属盐城医院内分泌科,224001

出　　处：《中华内分泌代谢杂志》2016年第1期42-46,共5页Chinese Journal of Endocrinology and Metabolism

摘　　要：目的探讨单纯性超重和肥胖人群血清胎球蛋白A（AHSG）水平的变化及其与相关临床指标的关系。方法从随机数字表法抽取的体检者中选取肥胖者49例，超重者176例，正常体重者327名；收集相关临床资料．酶联免疫法（ELISA）测定血清AHSG及脂联素水平；采用Pearson相关分析及多元线性回归模型分析AHSG与其它临床指标问的关系。结果血清AHSG水平在超重组及肥胖组中均明显高于正常体重组[（276．30和302．10对241．60）μg/ml]，肥胖组高于超重组（P〈0．05或P〈0．01）；在正常体重组中，AHSG与空腹血糖、稳态模型评估的胰岛素抵抗指数、C反应蛋白（CRP）、三酰甘油及游离脂肪酸（FFA）呈正相关，与年龄及脂联素呈负相关（P〈0．05或P〈0．01）；在超重和肥胖组中，AHSG除与上述指标呈显著相关性，与体重指数、腰臀比及低密度脂蛋白胆固醇亦呈正相关（P〈0．05或P〈0．01）；多元线性回归模型中，超重和肥胖组中的AHSG与腰臀比、CRP及FFA呈独立正相关，与脂联素呈独立负相关（P〈0．05或P〈0．01）。结论超重及肥胖者体内升高的AHSG可能是肥胖相关疾病的高危因素。Objective To investigate serum alpha2-Heremans-Schmid glycoprotein （AHSG） level and its relationship with associated clinical parameters in subjects with simple overweight and obesity. Methods Forty-nine subjects with obesity （ OB group）, 176 subjects with overweight （ OW group）, and 327 individuals with normal weight （ NW group） were randomly enrolled. The clinical data were collected and serum levels of AHSG and adiponectin （ APN ） were determined by ELISA. The associations of serum AHSG level with other clinical parameters were assessed by Pearson correlation analysis and multiple linear regressive model. Results Serum AHSG levels were higher in OW and OB groups than that in NW group[ （276.30 and 302.10 vs 241.60） μg/ml], being especially higher in OB group （P〈0.05 or P〈0.01 ）. Serum AHSG level in NW group was positively associated with fasting plasma glucose, homoeostasis model assessment of insulin resistance index, C-reactive protein （ CRP）, triglycerides, and free fatty acids （ FFA ） , but negatively associated with age and APN. In OW and OB groups, AHSG was also positively associated with body mass index, waist hip ratio （WHR） , and low density lipoprotein cholesterol （ P〈 0.05 or P 〈 0.01 ） except the aforementioned clinical parameters. In multiple linear regression model, AHSG was positively associated with WHR, CRP, and FFA, and was negatively associated with APN （P 〈 0. 05 or P 〈 0. 01 ）. Conclusion The raised AHSG level in overweight and obese subjects may be a risk factor for obesity-related diseases.

关 键 词：超重 肥胖 胎球蛋白A 

分 类 号：R587.1[医药卫生—内分泌]