有机毒物对小鼠和兔的半数致死剂量与大气环境质量标准的相关性研究  

Correlation research between LD_(50)(mouse)and LD_(50)(rabbit)of organic poison and its atmospheric environmental standards

作　　者：徐忠香 吴以中[1] 刘顿开 

机构地区：[1]南京工业大学环境学院,江苏南京211800

出　　处：《环境污染与防治》2016年第2期63-67,共5页Environmental Pollution & Control

摘　　要：《环境影响评价技术导则制药建设项目》(HJ 611—2011)指出在排放污染物未有参照值的情况下,毒理性质指标可参照多介质环境目标值(MEG)估算法计算,提出环境管理推荐控制限值。该估算法计算需使用大鼠经口给毒的半数致死剂量(LD50),而大量化学品国内外数据库中未完全给出大鼠LD50。针对毒性数据的局限性,通过大鼠、小鼠以及兔经口暴露途径收集有机毒物的LD50,采用统计分析法建立计算模式,来探究LD50(大鼠)与LD50(小鼠)、LD50(兔)以及与大气环境质量标准的相关性。研究表明,LD50(大鼠)与LD50(小鼠)、LD50(兔)确实存在极显著正相关性,并以此建立LD50(大鼠)与LD50(小鼠)、LD50(大鼠)与LD50(兔)的回归方程以及大气环境目标值(AMEGAH)的估算公式扩展方程,以推算环境评价中大气环境质量标准参考值。The environmental management recommended control limits can be estimated hy utihzing toxicity index referring to multimedia environmental goals （MEG） in the case of emission of pollutants without reference values, which was mentioned in ＂Technical guidelines for environmental impact assessment-Pharmaceutical construction al project＂ （HJ 611-2011）. This estimation method need use rat oral median lethal dose （LD50）, which a large num- ber of chemicals in both of the domestic and foreign database were not completely given. For the limitation of toxicity data, median lethal doses （LD50） of organic poisons were obtained across oral exposure route in rat, mouse and rabbit, using statistical analysis to establish the calculation mode to explore the correlation between LD50 （rat） and LD50 （mouse）, LD50 （rabbit） as well as atmospheric environmental quality standards. Research showed that there was a significant relationship between LD50 （rat） and LD50 （mouse）, LD50 （rabbit）, based on which, regression of LD50 （rat） and LD50 （mouse）, LD50 （rat） and LD50 （rabbit） as well as the extended equation of AMEGAH were built to calculate the reference value of atmospheric environmental quality standards in environmental assessment.

关 键 词：多介质环境目标值 半数致死剂量 统计分析 回归分析 大气环境目标值 

分 类 号：X503[环境科学与工程—环境工程] X823