脉复生对血栓闭塞性脉管炎患者血脂与血液流变学的作用  

Effects of Maifusheng decoction on serum lipid and hemorheology in patients with thromboangiitis obliterans

作　　者：周伟青[1] 刘若轩[2] 张洁[1] 邓志军[2] 郭洁文[2] 齐耀群 

机构地区：[1]广东省广州市中医医院检验科,510130 [2]广东省广州市中医医院药学部,510130

出　　处：《广东医学》2016年第1期130-132,共3页Guangdong Medical Journal

基　　金：广东省中医药管理局建设中医药强省科研课题(编号:20151065;20141227);广州市中医药和中西医结合科技项目(编号:20152A011011;20142A011012)

摘　　要：目的研究脉复生对血栓闭塞性脉管炎患者血脂和血液流变学的改善作用。方法将132例患者分为观察组和对照组,每组66例。对照组给予常规控制血压、控感染、抗凝、降糖、支持疗法、改善循环等基础治疗,观察组在基础治疗上加脉复生口服。3个疗程后观察两组患者治疗前后的血脂水平和血液流变学的变化。结果治疗前两组血脂水平及全血还原高切黏度、全血还原中切黏度、全血还原低切黏度、血浆黏度、红细胞聚集系数(VAI)、红细胞刚性指数(IR)、红细胞变形指数(TK)水平差异均无统计学意义,观察组治疗前、后比较,血清胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白B(APOB)、脂蛋白a[LP(a)]水平下降,高密度脂蛋白胆固醇、载脂蛋白A1、脂联素水平升高,全血还原高切黏度、全血还原中切黏度、全血还原低切黏度、血浆黏度、VAI、TK水平下降,IR水平提高(P<0.05);治疗后与对照组比较,观察组TC、TG、LDL-C、APOB、LP(a)水平均下降,全血还原高切黏度、全血还原中切黏度、全血还原低切黏度、血浆黏度、VAI、TK水平下降,IR水平升高(P<0.05)。结论脉复生能调节血栓闭塞性脉管炎患者血脂代谢,改善血液流变学。Objective To investigate the effects of Maifusheng decoction on serum lipid and hemorheology in pa- tients with thromboangiitis obliterans. Methods 132 patients with thromboangiitis obliterans were randomly divided into the treatment group and control group with 66 patients in each group. Patients in the control group were treated with rou- tine control of blood pressure and glucose, control in infection, anticoagulation, supportive therapy and circulation im- provement, while Maifusheng decoction was added in the treatment group. Changes of serum lipid and hemorheology in each group were observed after 3 courses of treatments. Results Levels of serum lipid, whole blood viscosity and plasma viscosity, VAI, IR and TK levels were not significantly different between the treatment group and the control group before therapy. TC, TG, LDL- C, APOB and LP（a） levels were reduced with increased levels of HDL -C, APOA1 and adi- ponectin in the treatment group（ P 〈 0. 05 ）. Whole blood viscosity and plasma viscosity, VAI and TK levels reduced and IR levels were elevated after therapy in the treatment group （P 〈 0. 05 ）. Levels of TC, TG, LDL - C, APOB, and LP （a） , whole blood viscosity and plasma viscosity, VAI and TK levels were lower and IR levels were higher in the treatment group than those in the control group after therapy（ P 〈 0. 05 ）. Conclusion Maifusheng can regulate lipid metabolism and improve hemorheology in patients with thromboangiitis obliterans.

关 键 词：脉复生 血栓闭塞性脉管炎 血脂 血液流变学 

分 类 号：R654.4[医药卫生—外科学]