微纳米粒子的形貌调控及其对药物/基因传递体系的影响  

Regulation the Morphology of Micro-and Nanoparticles and the Effect on Drug /Gene Delivery System

作　　者：刘亚杰[1] 张鹏[1] 杜建委 王幽香[1] 

机构地区：[1]教育部高分子合成与功能构造重点实验室浙江大学高分子科学与工程学系,杭州310027

出　　处：《化学进展》2016年第1期67-74,共8页Progress in Chemistry

基　　金：国家自然科学基金项目(No.21474087;51273177)资助~~

摘　　要：超分子组装体由于具有适合的微纳米尺寸、可控的结构和良好的生物相容性等特点,极大地促进了药物/基因传递体系的发展。拓扑结构(如形貌、尺寸)是影响药物/基因传递体系的重要因素,这方面研究正成为这一领域的研究热点。本文综述了调控组装体形貌的主要手段,包括聚合物链结构与组成、组装条件、外界刺激及聚合诱导的组装体形貌,初步探讨了微观形貌对药物/基因传递体系的影响,并对这一领域进行了展望。Supramolecular assembly has greatly promoted the development of drug/gene delivery system,due to the suitable micrometer or nanometer size,controllable structure and excellent biocompatibility.Recent studies have found that the topological structure plays a critical role in the drug/gene delivery process,which attracts great interest of researchers.In this paper,the main factors that regulate the morphology of micro-and nanoparticles are discussed,which mainly include composition of the copolymer,condition of self-assembly,external stimuli and polymerization-induced self-assembly.Then the effect of morphology on drug/gene delivery,challenges and prospects in this area are also discussed at the end of this review.

关 键 词：微纳米粒子 自组装 形貌调控 药物/基因载体 

分 类 号：O631[理学—高分子化学] Q782[理学—化学]