血液病患者预防性血小板输注的研究进展  被引量:16

Research progress of prophylactic platelet transfusions in patients with hematological diseases

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作  者:胡文静[1] 叶盛[1] 费荣[1] 蔡旭兵[1] 傅强[1] 周荣富[2] 

机构地区:[1]南京红十字血液中心,南京210003 [2]南京大学附属鼓楼医院

出  处:《临床血液学杂志》2016年第1期86-88,共3页Journal of Clinical Hematology

基  金:南京市医学科技发展(No:YKK14170);江苏省自然科学基金(No:BK2012529)

摘  要:预防性血小板输注是指通过输注血小板使各种血小板生成障碍患者,如恶性血液病、再生障碍性贫血(aplastic anemia,AA)、骨髓移植等患者的血小板计数(platelet count,PLT)提高到某一安全水平,达到防止出血的目的〔1〕。欧美国家超过70%的血小板输注为预防性输注,根据AABB的调查〔2〕,60%的医疗机构以PLT值20×109/L作为预防性输注的临界值。When platelet count falls below a certain threshold,the risk of bleeding will be significantly increased in patients with hematological diseases.In these patients,prophylactic platelet transfusion is an important measure to prevent intracranial hemorrhage.However,repeated apheresis platelet transfusion may lead to invalid transfusion.And platelet is a limited resource and very expensive.So domestic and foreign studies suggest that "platelet count lower than 20×109/L" is no longer a golden standard for platelet transfusion.Due to the different mechanisms of bleeding in aplastic anemia,primary immune thrombocytopenia,acute myelocytic leukemia,myelodysplastic syndrome,malignant lymphoma and other blood diseases,the tolerance of patents in low level of platelets is different.Further studies should be done to set platelet transfusion thresholds for various types of blood diseases.

关 键 词:预防性血小板输注 出血机制 血小板输注阈值 

分 类 号:R558[医药卫生—血液循环系统疾病]

 

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