中老年男子睾酮补充治疗的获益与风险  

Benefits and risks of testosterone supplementation therapy in the aging male

作　　者：李江源[1] 

机构地区：[1]解放军总医院内分泌科,北京100853

出　　处：《生殖医学杂志》2016年第2期105-112,共8页Journal of Reproductive Medicine

摘　　要：男子中年后血清睾酮水平逐渐降低,并可以引起瘦体量减少、体脂量增加、体能下降、血糖代谢失衡、骨密度降低、勃起功能障碍和情绪改变,需要给予睾酮补充治疗。可用的睾酮制剂包括口服十一酸睾酮,肌肉注射十一酸睾酮和庚酸睾酮,皮肤睾酮贴剂和凝胶以及皮下植入丸。睾酮补充治疗可以缓解因睾酮水平降低引起的症状和体征,但可能导致前列腺增生、前列腺癌、心血管疾病、红细胞增多和阻塞性睡眠呼吸暂停综合征的风险仍存在争议。Serum testosterone level is declined progressively with aging in men,which may associate with decreased lean body mass,increased body fat mass,loss of energy and well-being,imbalance of glycemic metabolism,decreased bone mineral density,erectile dysfunction,and changes of mood.It is necessary to treat the patients with testosterone supplementation therapy（TST）.Available testosterone preparations include oral testosterone undecanoate,intramuscularly injectable testosterone undecanoate or testosterone enanthate,transdermal gel and patches,and implant pellets.TST is able to improve the symptoms and signs resulted from the low serum level of testosterone,and its risks on prostate gland,cardiovascular disease,erythrocytosis and obstructive sleep apnea are controversial.

关 键 词：中老年男子 睾酮补充治疗 获益 风险 

分 类 号：R1[医药卫生—公共卫生与预防医学]