多巴酚丁胺负荷心肌灌注三维重塑对中年冠心病患者的诊断价值  被引量:2

Diagnostic value of dobutamine-stressed cardiac morphing myocardial perfusion imaging for coronary artery disease in middle-aged patients

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作  者:常城[1] 谢文晖[1] 雷贝[1] 王利华[1] 李若谷[2] 

机构地区:[1]上海交通大学附属胸科医院核医学科,200030 [2]上海交通大学附属胸科医院心内科,200030

出  处:《中华核医学与分子影像杂志》2016年第1期54-58,共5页Chinese Journal of Nuclear Medicine and Molecular Imaging

基  金:上海市胸科医院科技发展基金(YZ13-21)

摘  要:目的评价多巴酚丁胺负荷^99Tc^m-MIBI心脏三维重塑(CM)MPI(CMMPI)对中年冠心病患者的诊断价值。方法回顾性分析2011年3月至2015年2月间因胸闷、心悸、胸痛等症状就诊,临床怀疑冠心病的中年患者97例,其中男52例,女45例,年龄40~65(52.98±7.74)岁,检查前均签署知情同意书。所有患者均行常规一日法^99Tc^m-MIBI多巴酚丁胺负荷一静息CMMPI,并于1个月内行CAG进行对比分析,获得CMMPI对中年冠心病患者的诊断效能。结果CAG显示冠状动脉狭窄的51例患者中,CMMPI显示异常42例,无异常9例;CAG显示无异常的46例中,CMMPI显示异常11例,无异常35例。以CAG结果为“金标准”,CMMPI对中年冠心病患者诊断的灵敏度、特异性、准确性、阳性预测值和阴性预测值分别为82.35%(42/51)、76.09%(35/46)、79.38%(77/97)、79.25%(42/53)和79.55%(35/44)。多巴酚丁胺负荷试验的不良反应轻、时间较短,发生率为82.47%(80/97)。结论多巴酚丁胺负荷CMMPI对中年冠心病患者的诊断、心肌损害程度的评估具有重要价值。Objective To evaluate the diagnostic value of dobutamine-stressed cardiac morphing (CM) MPI (CMMPI) for coronary artery disease (CAD) in middle-aged patients. Methods A total of 97 middle-aged patients (52 males, 45 females, age 40-65 (52.98±7.74) years) from March 2011 to February 2015 with chest distress, cardiopalmus and chest pain symptoms (suspected CAD) were retrospectively studied. Informed consents were signed by patients before examination. All patients underwent one-day dobutamine-stressed/rest CMMPI and CAG within one month. The diagnostic value of CMMPI was assessed and compared with CAG. Results CMMPI revealed 42 abnormal cases and 9 normal cases in 51 cases with cor onary artery stenosis by CAG. CMMPI found 11 abnormal cases and 35 normal cases in 46 cases with normal coronary artery by CAG. In comparison with CAG, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of CMMPI were 82.35% (42/51), 76.09% (35/46), 79.38% (77/97), 79.25% (42/53)and 79.55% (35/44) respectively. The side effect was slight and transient with an incidence of 82.47% (80/97). Conclusion The dobutamine-stressed CMMPI has an important value for the diagnosis of CAD and the assessment of myocardial damage in middle-aged patients.

关 键 词:冠状动脉疾病 体层摄影术 发射型计算机 单光子 图像处理 计算机辅助 多巴酚丁胺 MIBI 

分 类 号:R541.4[医药卫生—心血管疾病]

 

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