新型深静脉旋切抽吸式取栓器的试制及模拟实验研究  

Trial- production and simulation experimental research of new deep venous rotary- cut suction thrombectomy device

作　　者：孙立剑[1] 闫士举[1] 宋成利[1] 

机构地区：[1]上海理工大学医疗器械与食品学院,上海200093

出　　处：《中国医学物理学杂志》2016年第2期151-156,共6页Chinese Journal of Medical Physics

基　　金：上海市教育委员会科研创新项目(12YZ097)

摘　　要：目的:试制旋切抽吸式取栓器并进行体外模拟实验,研究抽吸流量以及转速对取栓效果的影响,并对比同类机械取栓器。材料和方法:试制取栓器,设计流体模型并搭建实验平台,准备6组实验,每组实验10个血栓样本,每个样本质量保持无统计学差异(P>0.05),设置3组不同抽吸流量200 mL/min(A1),250 mL/min(B1),300 mL/min(C1)以及3组不同转速18 000 r/min(A2),25 000 r/min(B2),35 000 r/min(C2),实验过程中记录每一个样本质量,取栓时间和排出液体体积。结果:不同的抽吸流量情况下,取栓时间3者有显著差异(P<0.05)且与抽吸流量呈负相关性,液体排出量3组无明显差异(P>0.05),250 mL/min流量下取栓效果最好;不同的转速情况下3组实验取栓时间以及液体排出量均有显著差异(P<0.05),2 5000 r/min转速下取栓效果最好。对比同类取栓器,在取栓时间以及打通速率上均有明显优势。结论:新型取栓器体外实验血栓清除率较高,清除时间以及排除液体量较现有同类取栓器有明显优势,体外碎栓能力较优。Objective To trial-produce the rotary-cut suction thrombectomy device and conduct simulation experiment in vitro; to study on the impacts of suction flow rate and rotation speed on the thrombectomy effect, and the impacts were compared with those of the similar mechanical thrombectomy device. Methods Thrombectomy device was trial-produced; fluid model was designed; experimental platform was established. Sixty thrombus samples without any statistical differences were prepared for six groups, each group of ten samples （P〉0.05）. Three groups had different suction flow rates, respectively 200 mL/min （A1）, 250 mL/min （B1）, 300 mL/min （C1）. And the other three groups had different rotation speeds, respectively 18 000 r/min （A2）, 25 000 r/min （B2）, 35 000 r/min （C2）. The sample quality, thrombectomy time, and discharge amount during the experiment were recorded. Results With different suction flow rates, significant differences were found in the thrombectomy time among three groups （P〈0.05）, and the thrombeetomy time was negatively correlated with the suction flow rate; no significant differences were found in the liquid discharge amount （P〉0.05）; the B1 group with the suction flow rate of 250 mL/min had the best thrombectomy effect. With the different rotation speeds, significant differences were found in the thromhectomy time and the discharge amount （P〈0.05）, and the group with the rotation rate of 25 000 r/min had the best thrombectomy effect. Compared with the similar mechanical thrombectomy device, the proposed device had obvious advantages in the thrombectomy time and thrombectomy rate. Conclusion Compared with the similar mechanical thrombectomy device, the new thrombeetomy device has a higher thrombus removal rate in vitro and better thrombectomy effect in vitro, with obvious advantages in the clear time and liquid discharge amount.

关 键 词：旋切抽吸式 体外模拟实验 取栓 流体模型 

分 类 号：R318.6[医药卫生—生物医学工程]