非病毒载体递送微小RNA治疗肿瘤的研究进展  

Research progress in microRNA delivery by non-viral vectors for cancer therapy

作　　者：崔盼盼[1,2] 陈超[1,2] 赵娟娟[1,2] 雷良玉 陶弋婧 秦娜琳[1,2] 徐林[1,2] 

机构地区：[1]遵义医学院免疫学教研室暨贵州省生物治疗人才基地,贵州遵义563099 [2]贵州省普通高等学校特色药物肿瘤防治特色重点实验室,贵州遵义563099

出　　处：《遵义医学院学报》2016年第1期92-99,共8页Journal of Zunyi Medical University

基　　金：国家自然科学基金资助项目(NO:31370918);教育部新世纪优秀人才计划(NO:NCET-12-0661);贵州省高层次创新型人才项目;遵义医学院优秀青年人才项目(NO:152Y-001)

摘　　要：近年来,微小RNAs(microRNAs,miRNAs)在肿瘤基因治疗方面的研究取得了重要进展,而递送载体则成为miRNAs分子肿瘤基因治疗研究的热点。非病毒递送载体由于高安全性、低免疫原性、高转染效率以及易于制备等优势,具有重要的潜在临床应用价值。本文就目前代表性非病毒递送载体的种类及其在miRNAs肿瘤基因治疗方面的研究进展进行了综述。In recent years,important progress in microRNAs based tumor gene therapy has been reached,especially in its delivery carriers field. Non-virus delivery vector not only had characteristics of low immunogenicity,but also could effectively increase the tumor cell uptake rate and prevent the nuclease degradation effects. In this paper,the types of current representative non-target deliver carriers and its research progress in miRNAs based gene therapy of tumor are reviewed.

关 键 词：微小RNAS 递送系统 肿瘤 基因治疗 

分 类 号：Q782[生物学—分子生物学]