增生性糖尿病性视网膜病变患者房水细胞因子的改变及与血糖的相关性分析  

The changes in aqueous humor cytokines and its correlation with blood glucose in patients with proliferative diabetic retinopathy

作　　者：伍俊[1] 文智伟[1] 黄海涛[1] 

机构地区：[1]湖南省永州市爱尔眼科医院眼科,425000

出　　处：《临床眼科杂志》2016年第1期18-20,共3页Journal of Clinical Ophthalmology

摘　　要：目的探讨增生性糖尿病性视网膜病变(PDR)患者房水细胞因子的改变及与血糖的相关性。方法分析2013年1月至2015年1月在我院接受治疗的PDR患者的临床资料,列为观察组。另纳入单纯性年龄相关白内障患者作为对照组。结果共纳入观察组43例,对照组32例。观察组空腹血糖(FBG)水平显著高于对照组(t=11.040,P<0.001)。观察组患者房水肿瘤坏死因子-α(TNF-α)水平显著高于对照组(t=4.984,P<0.001)。观察组患者房水血管内皮生长因子(VEGF)水平显著高于对照组(t=18.860,P<0.001)。Pearson相关性检验显示观察组患者FBG水平与房水VEGF及TNF-α水平均呈现显著正相关,具有统计学意义(P<0.001)。结论 PDR患者房水高表达VEGF及TNF-α且与血糖水平正相关。Objective This study aimed to analyze the changes of cytokine expression in aqueous humor and its correlation with blood glucose level in patients with proliferative diabetic retinopathy（ PDR）.Methods Clinical data of PDR patients who received treatments at our hospital from 2014 to 2015 were analyzed（ Group A）.Age-related cataract patients were enrolled as control（ Group B）.Results A total of 75 patients were involved（ Group A n = 43; Group B n =32）.Group A patients had higher levels of fasting blood glucose（ FBG） than Group B patients,and the difference was statistically significant（t = 11.040,P〈 0.001）.Group A patients had higher levels of TNF-α and VEGF in aqueous humor than Group B patients,and the difference was statistically significant（P 〈 0.001）.Correlation analysis showed that for Group A patients,the levels of TNF-α and VEGF in aqueous humor were positively correlated with FBG（P 〈 0.001）.Conclusion Patients with proliferative diabetic retinopathy had high levels of TNF-α and VEGF in aqueous humor that may be involved in the development of retinopathy.

关 键 词：增生性糖尿病性视网膜病变 空腹血糖 房水 相关性分析 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]