德阳地区人乳头瘤病毒感染亚型、多重感染、年龄分布的流行病学研究  

Study on the epidemiology of Human Papilloma Virus subtypes,multiple infections,age distribution in Deyang region

作　　者：陈丽[1] 徐培[1] 刘倩[1] 丁兀兀[1] 李慧[1] 段芳蕾[1] 孟红[1] 吴宁[1] 

机构地区：[1]德阳市人民医院病理科,四川德阳618000

出　　处：《中国计划生育和妇产科》2016年第2期40-43,共4页Chinese Journal of Family Planning & Gynecotokology

摘　　要：目的了解四川省德阳地区宫颈组织中23种人乳头瘤病毒（Human papilloma virus,HPV）感染情况（亚型分布、单一和混合感染构成以及感染女性年龄分布）。方法对2014年1月至2015年1月在德阳市人民医院体检和就诊的3 008例女性的宫颈标本应用多聚酶链反应（polymerase chain reaction,PCR）-反向点杂交法进行HPV分型检测,并对所得数据进行统计分析。结果 3 008例标本中,阳性1 010例,感染率为33.58%;其中单一感染726例（70.88%）,单一高危型感染560例（18.62%）,单一低危型感染166例（5.52%）,单一感染例数是多重感染的2.56倍;多重感染284例（28.11%）,以双重感染为主（69.37%）;双重感染中以高危型和高危型混合感染为主（61.42%）,而三重及以上感染以高危型和低危型混合感染为主（73.56%）;41~50岁年龄段的患者感染最多,但≤20岁和〉50岁年龄段的患者组检出阳性率最高。结论德阳地区有较高的HPV感染率,且本地区HPV感染亚型和年龄段分布具有独特的区域特点。本研究结果可为本地区宫颈病变的诊断、治疗,宫颈癌的早期预防和HPV疫苗使用等提供重要的参考依据。Objective To study 23 kinds of Human Papilloma Virus（ HPV） infections of cervical tissues in Deyang region（ subtype distributions,single and mixed infections and age distribution of infected women）. Methods Applying PCR- reverse dot blot to detect the HPV genotyping of 3 008 female cases’ cervical specimens,who did physical examinations and treated in the people’s hospital of Deyang City from Jan. 2014 to Jan. 2015,and the resulting data were statistically analyzed. Results In 3 008 cases of specimens,there were 1 010 cases of positive results,and the infection rate was 33. 58 %. In which 726 cases belonged to the single infection（ 70. 88 %）. The single high- risk accounted for 560 cases,and the infection rate was 18. 62 %. The single low- risk accounted for 166 cases,and the infection rate was 5. 52 %. The number of the single infection was 2. 56 times of the multiple infections. There were 284 cases（ 28. 11 %） of multiple infections in 1 010 cases,and the most of which was the dual infections（ 69. 37 %）. In the dual infections,the mixed infections with high- risk and high- risk were dominant（ 61. 42 %）,while in the triple infections and more,the mixed infections with high- risk and low- risk were dominant（ 73. 56 %）. The most of patients infected were in the 40 ~ 50 age group. However,the highest positive rates were among ≤20 and 〉 50 years old group. Conclusion There was high prevalence of HPV in Deyang region. And the age and subtypes distribution of HPV infection were unique in this region. This study can provide important reference basis for the diagnosis and treatment of the cervical lesions,the prevention of the early cervical cancer and the use of HPV vaccine.

关 键 词：人乳头瘤病毒 德阳地区 多聚酶链反应 宫颈组织 

分 类 号：R711.74[医药卫生—妇产科学]