机构地区:[1]西藏自治区人民政府驻成都办事处医院内分泌代谢科,成都610044 [2]复旦大学附属华山医院心血管内科,上海200040
出 处:《复旦学报(医学版)》2016年第1期59-64,共6页Fudan University Journal of Medical Sciences
基 金:西藏自治区科技计划重点科研项目(Z2014A07G2-1)~~
摘 要:目的研究不同性别藏汉两族内分泌门诊患者的体脂分布差异。方法研究对象为2014年9月至11月在西藏自治区人民政府驻成都办事处医院内分泌科门诊就诊的汉族患者276例及藏族患者535例,收集患者性别、年龄、身高、体重、腰围、糖尿病病史和空腹血脂等信息。排除体质指数(body mass index,BMI)、年龄和糖尿病的影响后,采用t检验及多元回归分析比较藏汉两族患者的腰围及血脂差异。结果调整BMI后,藏族女性与汉族女性的腰围差异无统计学意义[(93.29±11.513)cmvs.(88.64±10.8)cm,P=0.396],藏族男性腰围显著大于汉族男性[(94.89±9.08)cmvs.(89.81±9.53)cm,P<0.001)]。分层分析显示,体重正常和超重的藏族男性腰围均大于汉族男性[(86.61±6.43)cmvs.(82.71±7.21)cm;(94.36±6.07)cmvs.(91.22±6.82)cm,P均<0.001)],但藏汉两族肥胖人群的腰围差异无统计学意义[(102.88±8.31)cmvs.(100.41±7.27)cm,P=0.112)]。调整糖尿病、BMI、性别和年龄后,藏族的三酰甘油(triglyceride,TG)水平均显著低于汉族[(1.52±0.91)mmol/L vs.(1.79±1.64)mmol/L,P<0.001)],高密度脂蛋白(high density lipoprotein cholesterol,HDL-c)水平低于汉族[(1.12±0.26)mmol/L vs.(1.21±0.35)mmol/L,P=0.019],低密度脂蛋白水平(low density lipoprotein cholesterol,LDL-c)高于汉族[(2.81±0.90)mmol/L vs.(2.55±0.87)mmol/L,P<0.001)]。结论调整BMI后,藏族男性腰围大于汉族男性,但在肥胖人群中未见差异。排除糖尿病、BMI、性别和年龄的影响后,藏族的TG水平显著低于汉族。Objective To preliminarily explore the difference of body fat distribution between Tibetan and Han people in our endocrinology outpatient clinic. Methods From Sep.to Nov.in 2014,535 Tibetan and 276 Han outpatients in the department of endocrinology and metabolism,Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region were included to the present study.The data including gender,age,height,body weight,waist circumference(WC),diabetes diagnosis and fasting blood-lipids were collected.After the adjustment of mass index body(BMI),age and diabetes mellitus,the differences in WC and lipid profiles between Tibetan and Han people were analyzed by t test and multiple regression analysis. Results There was no difference in WC between Tibetan and Han females[(93.29±11.513)cmvs.(88.64±10.8)cm,P=0.396]after the adjustment of BMI.However,Tibetan males WC was larger than Han males[(94.89±9.08)cmvs.(89.81±9.53)cm,P0.001],especially in the subjects of normal weight and overweight by stratified analysis[(86.61±6.43)cmvs.(82.71±7.21)cm;(94.36±6.07)cmvs.(91.22±6.82)cm,Pall0.001].While the difference of WC in obese males didn't have statistical significance between the two groups[(102.88±8.31)cmvs.(100.41±7.27)mmol/L,P=0.112].Compared with Han people after the adjustment of BMI,diabetes,gender and age,triglyceride(TG)level in Tibetan was lower[(1.52±0.91)mmol/L vs.(1.79±1.64)mmol/L],high density lipoprotein cholesterol(HDC-c)level was lower[(1.12±0.26)mmol/L vs.(1.21±0.35)mmol/L,P=0.019],and low density lipoprotein cholesterol(LDL-c)level was higher[(2.81±0.90)mmol/Lvs.(2.55±0.87)mmol/L,P0.001]. Conclusions Tibetan males had larger WC than Han males after the adjustment of BMI,however,the difference was declined with the increase of obesity degree.In comparison with Han people,Tibetan people had significant lower triglyceride levels after the adjustment of BMI,gender and age.
分 类 号:R33[医药卫生—人体生理学]
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