One-pot Synthesis of α,β-Dehydroamino Derivatives from β,β-Dicyanostyrene with 1,3-Dibromo-5,5-dimethylhydantoin Promoted by Mild Base  

作　　者：CHEN Zhanguo DU Manfei XIA Wei HU Junli 

机构地区：[1]Key Laboratory for Maeromolecular Science of Shaanxi Province, School of Chemistry and Chemical Engineering Shaanxi Normal University, Xi 'an 710119, P. R. China

出　　处：《Chemical Research in Chinese Universities》2016年第1期68-75,共8页高等学校化学研究（英文版）

基　　金：Supported by the Natural Science Foundation of Shaanxi Province, China（No.2009JM2001）, the Innovation Foundation of Postgraduate Cultivation of Shaanxi Normal University, China（No.2008CXB009） and the Fundamental Research Funds for the Central Universities of China（No.GK261001095）.

摘　　要：The reaction of β,β-dicyanostyrene derivatives（l） with 1,3-dibromo-5,5-dimethylhydantoin（DBDMH） was systematicly studied. The reaction could generate different products when promoted by different mild bases. When the reaction was promoted by NaOAc（100%, molar ratio to compound 1）, β,β-dicyanostyrene derivatives could be directly converted into corresponding α,β-dehydroamino derivatives in good to excellent yields in one-pot. When the reaction was promoted by K3PO4（80%, molar ratio to compound 1）, the corresponding α,β-dehydroamino and double-α,β-dehydroamino compounds were simultaneously obtained and the total conversion of β,β-dicyanostyrene derivatives was up to 90% or higher.The reaction of β,β-dicyanostyrene derivatives（l） with 1,3-dibromo-5,5-dimethylhydantoin（DBDMH） was systematicly studied. The reaction could generate different products when promoted by different mild bases. When the reaction was promoted by NaOAc（100%, molar ratio to compound 1）, β,β-dicyanostyrene derivatives could be directly converted into corresponding α,β-dehydroamino derivatives in good to excellent yields in one-pot. When the reaction was promoted by K3PO4（80%, molar ratio to compound 1）, the corresponding α,β-dehydroamino and double-α,β-dehydroamino compounds were simultaneously obtained and the total conversion of β,β-dicyanostyrene derivatives was up to 90% or higher.

关 键 词：β β-Dicyanostyrene derivative 1 3-Dibromo-5 5-dimethylhydantoin（DBDMH） α β-Dehydroamino 

分 类 号：TQ463[化学工程—制药化工] O636.1[理学—高分子化学]