HMGB1在慢性阻塞性肺疾病患者中的水平变化及相关性分析  

Analysis of the level of HMGB1 in patients with chronic obstructive pulmonary disease

作　　者：郑爱玲[1] 林松娟[2] 高增艳[2] 王萍[2] 丁芳[2] 

机构地区：[1]潍坊医学院内科学教研室,山东261031 [2]潍坊医学院附属医院

出　　处：《社区医学杂志》2016年第2期14-16,共3页Journal Of Community Medicine

摘　　要：目的探讨慢性阻塞性肺疾病(chronic obstructive plumonary disease,COPD)患者急性加重期治疗前后血清高迁移率族蛋白B1(high mobility group protein B1,HMGB1)的水平变化及其与肺功能的相关性。方法选取2014年10月—2015年6月COPD急性加重期患者72例,依据肺功能将其分为两亚组:GOLD 1、2级患者36例,GOLD 3级患者36例,另选取对照组36例,采用ELISA法分别测定所有对象的血清HMGB1水平,并行肺功能检测,计量资料比较采用t检验,相关关系采用Pearson相关性分析,P<0.05为差异有统计学意义。结果 COPD急性加重患者治疗前及治疗后血清HMGB1表达水平均明显高于对照组[(5.47±1.69)、(3.41±0.99)、(1.95±0.16)μg/L],对比差异均有统计学意义(均P<0.05)。GOLD 3级COPD患者治疗前及治疗后血清HMGB1表达水平明显高于GOLD 1、2级COPD患者治疗前及治疗后[(6.84±1.21)、(4.11±0.70)、(4.17±0.85)、(2.66±0.32)μg/L],对比差异均有统计学意义(均P<0.05)。COPD患者血清HMGB1水平与FEV1%pred呈显著负相关(r=-0.749,P<0.05)。结论血清HMGB1在COPD患者中表达水平明显升高,且与病情严重程度呈显著相关,提示检测血清HMGB1对COPD病情严重程度的判断有一定意义。Objective To explore the changes and correlation between high mobility group protein BI（HMGB1） and lung function of serum levels of ttMGB 1 in the patients with chronic obstructive pulmonary disease（COPD） before and after treatment.Methods 72 eases patients with acute exacerbation of COPD,according to the pulmonary function were divided into two subgroups from Octo- ber 2014 to June 2015,GOLD 1,2 grade patients with 36 cases,GOLD 3 grade patients with 36 cases,then control group with 36 cas- es,to detect the serum levels of HMGB1 in acute exacerbation of COPD before treatment, after treatment of acute exacerbation of COPD and healthy subjects（control group）,which were measured by enzyme-linked immunosorbent assay（ELISA）,and pulmonary function test was performed,measurement data was processed by t test,the result of p〈0.05 was considered statistically significant.Re- suits COPD expression level of HMGB1 in patients with acute exacerbation of patients before and after treatment were higher than those of the contrul group [（5.47 ± 1.69）,（3.41 ± 0.99）,（1.95 ± 0.16）μg/L],the differences were statistically significant（aU P〈0.05）.Serum levels of HMGBI in GOLD 3 grade COPD before and after treatment were higher than that in GOLD 1,2 grade COPD [（6.84 ± 1.21）,（4.11 ±_0.70）,（4.17 ±0.85）,（2.66 ± 0.32）μg/L],the differences were statistically significant（all P〈0.05）.Serum levels of HMGB1 were significant negative correlated with FEV1%pred（r=-0.749,P〈0.05）.Conclusion The expression level of serum HMGB I in patients with COPD was significantly increased,and it was significantly correlated with the severity of the dis- ease.It was suggested that the detection of serum HMGB1 had a certain significance with the severity of COPD.

关 键 词：慢性阻塞性肺疾病 高迁移率族蛋白1 一秒钟用力呼气容积占预计值百分比 

分 类 号：R563[医药卫生—呼吸系统]