牙疼舒滴丸的抗炎镇痛实验研究  

Anti-inflammatory and analgesic effects of toothache drop pills

作　　者：王盟[1] 邓莉[2] 刘辉[1] 赵亚鑫[3] 张爱兰[2] 

机构地区：[1]山东省济宁市第一人民医院医务部,272011 [2]山东省济宁市第一人民医院医疗保险部,272011 [3]山东省济宁市第一人民医院药学部,272011

出　　处：《国际中医中药杂志》2016年第2期149-152,共4页International Journal of Traditional Chinese Medicine

基　　金：山东省济宁市科技发展计划资助项目（2013jnwk113）

摘　　要：目的研究牙疼舒滴丸的抗炎镇痛作用。方法采用二甲苯致小鼠耳廓肿胀、蛋清致小鼠足掌肿胀2种急性炎症模型及棉球致小鼠肉芽肿胀慢性炎症模型，观察牙疼舒滴丸的抗炎作用。采用热板法和醋酸扭体法致痛，观察牙疼舒滴丸的镇痛作用。结果与空白对照组比较，阳性对照组，牙疼舒滴丸中、高剂量组小鼠耳廓肿胀度[（2．56±1．35）mg、（4．26±1．21）mg、（3．23±1．25）mg比（8．25±1．21）mg]降低（P〈0．05）；给药后120min，与空白对照组比较，阳性对照组，牙疼舒滴丸中、高剂量组小鼠足掌肿胀度[（23．54±9．12）mg、（27．58±9．14）mg、（21．25±8．45）mg比（39．54±8．89）mg]、棉球致小鼠肉芽肿胀质量[（6．51±2．58）mg、（7．82±1．57）mg、（6．58±3．47）mg比（13．58±3．25）mg]下降（P〈0．05）；小鼠热板痛阈值[（20．86±2．58）s、（20．25±2．14）s、（20．75±1．78）s比（17．21±3.31）s]升高（P〈0．05）；扭体次数[（23．47±7．57）次、（28．65±6．54）次、（24．36±7．78）次比（40．96±6．58）次]减少（P〈0．05）。结论牙疼舒滴丸具有显著的抗炎镇痛作用。Objective To investigate the anti-inflammatory and analgesic effects of toothache drop pills. Methods The acute inflammatory models such as xylene-induced ear edema and egg white-induced paw edema and the chronic inflammatory model granuloma induced by cotton pellet implantation were used in researching the inflammatory effects of toothache drop pills. Meanwhile, the analgesic effects of toothache drop pills were observed by hot plate and acetic acid writhing test. Results Compared with the blank control group, the degree of ear swelling in mice in the positive control group, toothache drop pills middle and high dose group （2.56 ± 1.35 mg, 4.26 ± 1.21 mg, 3.23 ± 1.25 mg vs. 8.25 ± 1.21 mg） were lower than the blank control group （P〈0.05）. 120 minutes after administration,compared with the blank control group, the degree of paw swelling in mice in the positive control group, toothache drop pills middle and high dose group （23.54 ± 9.12 mg, 27.58 ± 9.14 mg, 21.25 ± 8.45 mg vs.39.54 ± 8.89 mg） were lower than the blank control group （P〈0.05）. Granuloma swelling quality in mice caused by cotton inthe positive control group, toothache drop pills middle and high dose group （6.51 ± 2.58 mg, 7.82 ± 1.57 mg, 6.58 ± 3.47 mg vs. 13.58 ± 3.25 rag） were lower than the blank control group （P〈0.05）. The threshold of pain in mice in the positive control group, toothache drop pills middle and high dose group （20.86 ± 2.58 s, 20.25 ± 2.14 s, 20.75 ± 1.78 s vs.17.21 ± 3.31 s） were increased （P〈0.05）. The number of mice writhing in the positive control group, toothache drop pills middle and high dose group （23.47 ± 7.57, 28.65 ± 6.54, 24.36 ± 7.78 vs. 40.96 ± 6.58） were decreased（P〈0.05）. Conclusion Toothache drop pills had obvious anti-inflammatory and analgesic effects.

关 键 词：牙疼舒滴丸 抗炎 镇痛 小鼠 

分 类 号：R285.5[医药卫生—中药学]