龙血竭散联合美沙拉嗪缓释片灌肠治疗溃疡性结肠炎  

Longxuejie powder in combined with mesalazine tablets enema in treatment of ulcerative colitis

作　　者：赵敏[1] 王振军[2] 许艳春[3] 

机构地区：[1]首都医科大学全科医学与继续教育学院延庆医院普外科,北京102100 [2]首都医科大学附属北京朝阳医院普通外科,北京100020 [3]中国人民解放军第251医院,河北张家口075000

出　　处：《长春中医药大学学报》2016年第1期115-118,共4页Journal of Changchun University of Chinese Medicine

基　　金：北京军区医疗成果项目(2009229)

摘　　要：目的观察美沙拉嗪缓释片联合龙血竭散灌肠对溃疡性结肠炎(UC)的疗效。方法收集70例UC患者,随机分为观察组和对照组,各35例,2组均给予相应调节酸碱失衡、水电解质紊乱及改善营养状况等治疗。对照组以美沙拉嗪缓释片1.0 g口服,4次/d,观察组在对照组基础上给予龙血竭散1.0 g溶于生理盐水150 m L进行灌肠,肠道保留1 h,1次/d,均连续治疗4周。观察治疗前后IL-8、IL-10、TNF-α、红细胞压积、纤维蛋白原、全血黏度水平,并进行疗效评价。结果治疗后IL-8、TNF-α明显降低,IL-10明显升高,且观察组优于对照组(P<0.05);治疗后红细胞压积、纤维蛋白原、全血黏度水平观察组降低程度优于对照组(P<0.05);观察组总有效率91.4%,对照组71.4%(P<0.05)。结论美沙拉嗪口服联合龙血竭散灌肠可以明显减轻UC患者炎性反应,改善血液高凝状态,提高治疗效果,改善患者生活质量。Objective To analyze the effect of Longxuejie powder in combined with mesalazine tablets enema in the treatment of ulcerative colitis（ UC）. Methods A total of 70 patients with UC who were admitted in our hospital from August,2014 to August,2015 were included in the study and randomized into the observation group and the control group. The patients in the two groups were given corresponding adjustment of acid-base imbalance and water and electrolyte disturbance,and the improvement of nutritional status. The patients in the control group were orally given mesalazine tablets（ 1. 0 g）,four times a day. On this basis,the patients in the observation group were given Longxuejie powder（ 1. 0 g）,dissolving in 150 m L normal saline for enema,retaining in the intestinal tract for 1h,once a day. The patients in the two groups were given a continuous 4-week treatment. The levels of IL-8,IL-10,TNF-α,HCT,fibrinogen,and whole blood viscosity before and after treatment in the two groups were observed,and the efficacy was evaluated. Results After treatment,the levels of IL-8 and TNF-α were significantly reduced,while the IL-10 level was significantly elevated,moreover,the degree in the observation group was significantly superior to that in the control group（ P〈0. 05）. The decreased degree of the levels of HCT,fibrinogen,and whole blood viscosity after treatment in the observation group was significantly superior to that in the control group（ P〈0. 05）. The total effective rate in the observation group（ 91. 4%） was significantly higher than that in the control group（ 71. 4%）（ P〈0. 05）. Conclusion Longxuejie powder in combined with mesalazine tablets enema in the treatment of UC can significantly reduce the inflammatory reaction,improve the hypercoagulable state,enhance the therapeutic effect,and improve the patients＇ living qualities.

关 键 词：美沙拉嗪缓释片 血竭散 保留灌肠 溃疡性结肠炎 

分 类 号：R256.35[医药卫生—中医内科学]