中国8个长寿地区40岁以上人群血清SOD，MDA和hsCRP水平与高血压、糖尿病的相关研究  

Investigation and Analysis of the Relationship of Hypertension and Diabetes with Superoxide Dismutase, Malondialdehyde, Hypersensitive C-Reactive Protein in 8 Longevity Areas in China of People Aged 40 and Over

作　　者：白雪梅[1] 于培红[1] 殷召雪[2] 施小明[2] 

机构地区：[1]首都医科大学,北京100069 [2]中国疾病预防控制中心慢性病防治与社区卫生处,北京102206

出　　处：《现代检验医学杂志》2016年第1期12-16,共5页Journal of Modern Laboratory Medicine

基　　金：国家自然科学基金（71110107025,71233001,71490732,81273160）.

摘　　要：目的研究中国长寿地区中、老年人超氧化物歧化酶（SOD）、丙二醛（MDA）、超敏C反应蛋白（hsCRP）在增龄过程中的变化和高血压、糖尿病与上述三个指标的关系。方法以中国8个长寿之乡参加2014年长寿县市“老年人口健康状况的生物医学研究”的居民作为目标对象，有2467名40岁以上人群参加调查且留取了足量的静脉血，其中40～岁组22名，60～岁组249名，70～岁组521名，80～岁组679名，90～岁组548名，100～岁组448名。采用自行设计的调查表收集社会人口学特征等信息，由临床医生采用统一的检查工具对研究对象进行体检。空腹采集静脉血，检测SOD，MDA，hsCRP和GLU。并比较不同年龄组、不同性别上述三个指标含量的差异和高血压、糖尿病不同患病情况的受试者上述三个指标的差异。结果40～，60～，70～，80～，90～和100～岁男性SOD分别为55．55±8．82，54．49±6．74，55．47±8．42，56．40±8．37，57．45±8．71和57．38±7．72U／ml，各组之间的差异有统计学意义（F=3．398，P〈0.01），女性为59．36±lo．98，56．08±7．98，57．41±8．54，57．38±8．18，59．16±7．71和57．90±8．66U／ml，各组之间的差异有统计学意义（F=2．667，P〈0.01）；男性MDA分别为6．92土4．02，6．10±4．35，5．66±3．83，5．834-3．66，5．39±2．68和4．80±2．34μmol／L，各组之间的差异无统计学意义（F=2．198，P=0.052），女性MDA分别为8．93±8．20，7．23±4．57，6．47土3．67，6．42±4．12，5．59±2．88和5．85±3．73μmol／L，各组之间的差异有统计学意义（F=4．434，P〈0.01）；男性hsCRP阳性率分别为11．8％（2／17），14．8％（26／176），19．3％（62／322），23．5％（77／327），26．1％（57／218）和43．4％（33／76），各组之间的差异有统计学意义（χ^2=29．914，P〈0.01）；女性hsCRP阳性率分别为20.0％（1／5），1Objective To investigate the changes of superoxide dismutase （SOD） ,malondialdehyde （MDA） ,hypersensitive creactive protein （hsCRP） in the process of age changes,in longevity areas in China, and the relationship between the above three indicators and hypertension and diabetes. Methods Residents who participated in the project of biomedical research of aging population conducted in 2014 were selected from 8 longevity Areas in China. 2 467 people aged 40 and over attended the study,including 22 aged 40 and over,249 aged 60 and over,521 aged 70 and over,679 aged 80 and over,548 aged 90 and over,448 aged 100 and over. Information,including socio-demographic, were collected by self-designed questionnaire. Calibrated instruments were used by the clinical personnel who had worked over 3 years to manually check subjects＇ heath. The fasting blood samples were collected by vacuum tube at early morning. The contents of plasma SOD, MDA,hsCRP and glucose were detected and compared among these elderly who were classified into different genders and different age groups. At the same time,compare the above three indicators of different subjects of hypertension,diabetes prevalence. Results In the groups aged 40 and over,60 and over,70 and over,80 and over,90 and over,100 and over,SOD were 55.55±8.82,54.49±6.74,55.47±8.42,56.40± 8.37,57.45 ±8.71 and 57.38± 7.72 U/ml respectively in males, the difference between groups showed statistically significant （F=3. 398,P〈0.01） and 59.36±10.98,56.08±7.98,57.41±8.54,57.38±8.18,59.16±7.71 and 57.90 ± 8.66 U/ml respectively in females, the difference between groups showed statistically significant （F= 2. 667,P〈0. 01）;MDA were 6.92±4.02,6.10±4.35,5. 66±3.83,5. 83±3.66,5.39±2. 68 and 4.80±2. 34 μmol/L respectively in males, the difference between groups were not statistically significant （F= 2.198, P= 0. 052） and 8.93± 8.20, 7.23±4.57,6.47±3.67,6.42±4.12,5.59±2.88 and 5.85±3.73μmol/L respectively in females,the difference between groups show

关 键 词：增龄 超氧化物歧化酶 丙二醛 超敏C反应蛋白 

分 类 号：R544.1[医药卫生—心血管疾病] R587.1[医药卫生—内科学]