肿瘤相关性贫血患者Neogenin的表达特点及其与Hepcidin，SF的关联性研究  

Expression and Significance of Neogenin, Hepcidin and SF in the Anemia Patients with the Tumor

作　　者：史玉娟[1] 陆晔[1] 王金湖[1] 程旭[1] 潘湘涛[1] 

机构地区：[1]苏州大学附属太仓医院,江苏太仓215400

出　　处：《现代检验医学杂志》2016年第1期71-72,76,共3页Journal of Modern Laboratory Medicine

基　　金：2013年苏州市社会发展科技项目（SZD2012080）.

摘　　要：目的研究肿瘤相关性贫血患者中再生蛋白（Neogenin）的表达特点，以及与铁调素（Hepcidin），血清铁蛋白（SF）的关系及其意义。方法应用双抗夹心生物素-亲和素-酶联免疫吸附试验方法检测55例肿瘤贫血患者和52例无贫血肿瘤患者的血清Neogenin，Hepcidin和SF水平，并分析它们之间的相互关系。结果①贫血组Neogenin为0．77±0．45ng／ml，明显低于无贫血组（0．98±0．60ng／ml）（t=2．0038，P〈0．05）；Hepcidin则为6．03±4．25μg／L，显著高于无贫血组（4．51±2．23μg／L）（t=2．3195，P〈0．05）。②贫血组SF虽也高于无贫血组，但差异无统计学意义（t=1．8980，P〉0．05）。③Hb与Neogenin呈正相关关系（r=0．2124，t=2．2264，P〈0．05），与Hepcidin呈负相关关系（r=-0．3101，t=3．3452，P〈0．01），而与SF无相关关系（P〉0．05）。④Neogenin与Hepcidin和SF均无明显相关关系（均P〉0．05）。但Hepcidin与SF呈正相关关系（r=0．4866，P〈0．01）。结论肿瘤贫血患者低表达Neogenin，高表达Hepcidin。Neogenin与Hb呈正相关，Hepeidin与Hb呈负相关。Neogenin和Hepcidin在肿瘤贫血的发生发展中起重要的作用。Objective To study the expression and significance of Neogenin, Hepcidin and serum ferritin（SF） in patients with cancer-related anemia. Methods To test the serum levels of Neogenin, Hepcidin and SF in 107 cases,including 55 cases with cancer-related anemia and 52 cases of non-anemia with tumor by ABC-ELISA. Results ①The serum levels of Neogenin in patients with cancer-related anemia were 0.77 ±0.45 ng/ml, which were lower than 0.98 ± 0.60 ng/ml in non-anemia group （t= 2. 003 8, P〈0.05）. The serum levels of Hepcidin in patients with cancer-related anemia were 6.03±4.25/μg/ml, which was higher than 4.51±2.23μg/ml in non-anemia group （t=2. 319 5,P〈0.05）. ②There were no difference in patients between anemia and non-anemia （t= 1. 898 0,P〉0.05）. ③In patients with cancer, there were positive correlation between Neogenin and Hb （r= 0. 212 4, t= 2. 226 4, P%0.05）, there were negtive correlation between Hepcidin and Hb （r= -0. 310 1 ,t=3. 345 2 ,P〈0.01） ,but there were no correlation between SF and Hb （P〉0.05）. ④There were positive correlation between Hepsidin and SF （r=0. 486 6,P〈0.01）. Conclusion There were lower expression of Neogenin,higher expression of Hepcidin in patients with cancer-related anemia is a complex process. The abnormal expression of Neogenin and Hepcidin which were lead to the loss of use of iron are the key factors attribute to anemia in patients with cancer.

关 键 词：再生蛋白 铁调素 铁蛋白 肿瘤相关性贫血 

分 类 号：R556.9[医药卫生—血液循环系统疾病] R392.11[医药卫生—内科学]