低分子肝素联合硫酸镁对妊娠期高血压的临床疗效探讨  

Clinical Effect of Low Molecular Weight Heparin Combined with Magnesium Sulfate in the Treatment of Pregnancy Induced Hypertension

作　　者：郑少冰 李育宜 黄宝荣 黄金娜 

机构地区：[1]汕头市潮南区人民医院,广东汕头515144

出　　处：《深圳中西医结合杂志》2016年第1期1-3,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：汕头市科技计划项目资助课题(汕府科[2013]88号)

摘　　要：目的:探讨低分子肝素联合硫酸镁治疗妊娠期高血压的临床效果。方法:选取本院2013年6月-2014年7月收治的妊娠期高血压患者共84例作为研究对象,使用随机数字表法分为观察组以及对照组各42例。其中对照组患者给予单独硫酸镁治疗,观察组给予低分子肝素联合硫酸镁治疗,观察两组患者治疗效果,比较两组患者治疗前后血小板计数、凝血酶原时间、红细胞压积以及D-二聚体的测定结果,同时统计两组患者产后2 h的出血量。结果:两组患者治疗后红细胞压积以及D-二聚体水平相较于治疗前均发生明显改变,同时观察组患者治疗后红细胞压积以及D-二聚体水平相较于对照组患者明显更低,两者比较,差异具有统计学意义(P<0.05)。两组患者治疗后血小板计数以及凝血酶原时间与治疗前比较,差异无统计学意义(P>0.05)。观察组患者产后2 h出血量与对照组比较,差异无统计学意义(P>0.05)。结论:低分子肝素联合硫酸镁治疗妊娠期高血压患者有着良好的效果,能够显著改善患者体内高度血凝状态,相较于单独使用硫酸镁治疗时疗效更为显著。Objective To investigate the clinical effect of low molecular weight heparin combined with magnesium sulfate in the treatment of hypertensive disorder complicating pregnancy. Methods 84 patients with hypertension were randomly divided into observation group and control group with 42 cases in each group. The control group was treated with magnesium sulfate, and the observation group was treated with low molecular weight heparin combined with magnesium sulfate. Results After treatment, the red blood cell volume and the level of D- two in the observation group were lower than those in the control group （P 〈 0.05）. The bleeding volume of 2 h in the observation group was compared with that of the control group （P 〉 0.05）. Conclusion Low molecular weight heparin combined with magnesium sulfate in the treatment of high blood pressure in pregnancy, can improve the patients with high blood coagulation state.

关 键 词：低分子肝素 硫酸镁 妊娠期高血压 凝血酶原时间 

分 类 号：R714.246[医药卫生—妇产科学]