孕产妇不良妊娠结局危险因素的病例对照研究  

Risk factors of maternal adverse pregnancy outcomes based on a case-control study

作　　者：魏小华[1] 雷春梅[1] 闫慧[1] 李姗姗[1] 屈鹏飞[1] 

机构地区：[1]西安交通大学第一附属医院妇产科,陕西西安710061

出　　处：《中国妇幼健康研究》2016年第1期23-25,共3页Chinese Journal of Woman and Child Health Research

基　　金：国家自然科学基金资助项目(No:81230016)

摘　　要：目的探讨孕产妇不良妊娠结局的危险因素。方法采用以医院为基础的非匹配病例对照研究,收集产妇一般情况、既往生育史、孕期异常状况及患病等资料,使用单因素X^2检验和多因素Logistic回归进行分析。结果单因素分析显示,病例组产妇高龄、职业为农民、不良妊娠史、早孕期异常、胎位异常、妊娠合并症的比例高于对照组,差异均有统计学意义(X^2值分别为9.529、13.512、10.134、4.465、11.586、31.562,均P<0.05)。多因素非条件Logistic回归分析表明,职业为农民(OR=2.298,95%CI:1.202~4.396)、不良妊娠史(OR=1.612,95%CI:1.150~2.260)、早孕期异常(OR=1.897,95%CI:1.142~3.152)、胎位不正(OR=3.067,95%CI:1.536~6.126)、妊娠合并症(OR=2.539,95%CI:1.764~3.656)为不良妊娠结局的危险因素。结论鼓励育龄期妇女优生优育,加强围孕期健康教育,孕妇应定期产检,发现异常及时就诊,以减少不良妊娠结局的发生。Objective To explore risk factors of maternal adverse pregnancy outcomes .Methods A unmatched case-control study based on hospital was performed , and univarite and multivariate Logistic regression analysis were conducted to analyze related factors of maternal adverse pregnancy outcomes , including general condition , history of fertility , abnormal symptoms and disease during pregnancy .Results Univarite analysis results showed that the proportions of pregnant women with advanced age , being farmers, history of adverse pregnancy , abnormalities in early pregnancy , abormal presentation , pregnancy complications were higher in case group than in control group with statistical significance （χ^2 value was 9.529, 13.512, 10.134, 4.465, 11.586 and 31.562, respectively, all P〈0.05）.Multivariate Logistic regression analysis showed that being farmers （OR=2.298, 95%CI： 1.202 -4.396）, history of adverse pregnancy （OR=1.612, 95%CI：1.150-2.260）, abnormalities in early pregnancy （OR =1.897,95%CI： 1.142 -3.152）, abnormal presentation （OR=3.067, 95%CI：1.536-6.126）, pregnancy complications （OR=2.539, 95%CI：1.764-3.656） were risk factors of maternal adverse pregnancy outcomes .Conclusion Prepotency should be advocated among fertile woman , and prenatal health education should be strengthened .Pregnant woman should take antenatal examination regularly , and once abnormal symptoms appear , they should see doctor in time to reduce the incidence of adverse outcomes .

关 键 词：不良妊娠结局 危险因素 非匹配病例对照研究 多因素Logistic回归 

分 类 号：R714.2[医药卫生—妇产科学]