妊娠合并肾病综合征54例临床研究  

Clinical study of 54 cases of pregnancy complicated with nephrotic syndrome

作　　者：王霖霖[1] 丁慧青[1] 陈丕平[1] 舒静[1] 

机构地区：[1]宁波市第一医院妇产科,浙江宁波315010

出　　处：《中国妇幼健康研究》2016年第1期92-93,106,共3页Chinese Journal of Woman and Child Health Research

摘　　要：目的探讨妊娠合并肾病综合征患者的妊娠结局及肾功能的变化。方法回顾性调查宁波市第一医院自2008年1月至2014年12月间的54例妊娠合并肾病综合征患者(观察组)和随机选取的54例正常妊娠患者(对照组)的临床资料。比较两组临床资料,并进一步分析影响胎儿预后的危险因素。结果肾病综合征组血浆总蛋白、终止孕周数均显著低于对照组(t值分别为4.09、3.30,均P<0.05),收缩压、舒张压、血肌酐、尿素氮、胆固醇、尿蛋白量、尿酸均显著高于对照组(t值分别为2.72、2.93、4.14、4.09、2.47、10.17、5.44,均P<0.05)。肾病综合征组新生儿窒息发生率显著高于对照组(X^2=4.43,P<0.05),产后出血发生率高于对照组,但无统计学意义(X^2=3.20,P>0.05)。Logistic回归分析显示,高收缩压的危险系数最高(OR=4.36,P<0.05),高肌酐值次之(OR=3.54,P<0.05)。结论妊娠合并肾病综合征患者并发症多,对胎儿影响大,其中高血压及高肌酐值是威胁胎儿的首要危险因素。Objective To explore pregnancy outcomes and alteration of renal function of pregnant women with nephrotic syndrome （ NS） . Methods From January 2008 to December 2014, clinical data of 54 pregnant women with NS （ observation group ） and another 54 randomly selected cases with normal pregnancy （ control group ） in Ningbo First Hospital were retrospectively analyzed and compared , and risk factors influencing neonatal outcomes were also analyzed .Results Serum total protein and the weeks of gestational in the observation group were significantly lower than the control group （t value was 4.09 and 3.30, respectively, both P〈0.05）, but systolic pressure, diastolic pressure , serum creatinine , urea nitrogen , cholesterol , urine protein and uric acid in the observation group were significantly higher than in the control group （t value was 2.72, 2.93, 4.14, 4.09, 2.47, 10.17 and 5.44, respectively, all P〈0.05）.The incidence of neonatal asphyxia was significantly higher in the observation group than in the control group （χ2 =4.43,P〈0.05）.The incidence of postpartum hemorrhage was higher in the observation group , but the difference was not significant （χ2 =3.20,P〉0.05）.Logistic regression analysis showed that the risk coefficient of hypertension （OR=4.36,P〈0.05） was highest, followed by high serum creatinine （OR=3.54, P〈0.05）.Conclusion More complications and risk occur in pregnancy complicated with NS .Hypertension and high serum creatinine are the primary risk factors of fetus .

关 键 词：妊娠 肾病综合征 肌苷 新生儿窒息发生率 

分 类 号：R714.2[医药卫生—妇产科学]