职业应激与职工唾液中皮质醇浓度的相关性分析  

Correlation between occupational stress and salivary cortisol concentration in employees

作　　者：田宏迩[1] 马蕾[1] 刘留留 张宏[1] 刘剀剡 张庆东[2] 朱新云[2] 朱华斌[2] 

机构地区：[1]东南大学公共卫生学院,南京210009 [2]扬中市疾病预防控制中心

出　　处：《中华劳动卫生职业病杂志》2016年第2期121-123,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：教育部人文社会科学研究规划基金（14YJA840012）;江苏省2015年度普通高校研究生科研创新计划项目（SJLX15_0070）;东南大学大学生科研训练计划（sRTP）项目（15422023）

摘　　要：目的研究职业应激对职工唾液中皮质醇浓度的影响。方法于2014年9月对186名某太阳能光伏企业职工进行职业应激程度评定，同时采用酶联免疫吸附（ELISA）试验测定其唾液中皮质醇浓度。结果职工人口学特征不同组间唾液中皮质醇浓度差异均无统计学意义（P〉0．05）；工作控制评分高水平组的皮质醇浓度[（74．62±15．34）μg／L]低于低水平组[（79．95±12．99）μg/L]，差异有统计学意义（P〈0．05）；工作危险、工作责任与负荷评分高水平组的皮质醇浓度分别为（80．29±9．45）、（80．94±10．87）μg/L]，明显高于低水平组[（75．60±16．41）、（74．05±16．35）μg／L]，差异均有统计学意义（P〈0．05）；皮质醇浓度与工作危险、工作责任与负荷评分呈正相关（r=-0．176、O．252，P〈0．05），与工作控制评分呈负相关（r=0．208，P〈0．05）。结论唾液中皮质醇浓度与职业应激呈正相关，随着职业应激程度升高而升高，可作为职业应激识别与评价的客观生物标志物。Objective To investigate the influence of occupational stress on salivary cortisol concentration in employees. Methods In September 2014, occupational stress evaluation was performed for 186 employees in a solar photovohaic company, and enzyme-linked immunosorbent assay was used to measure the salivary cortisol concentration. Results The salivary cortisol concentration showed no significant differences between groups with different demographic features （P〉0.05）. The group with a high score of job control had a significantly lower salivary cortisol concentration than that with a low score （74.62±15.34μg/L vs 79.95±12.99 μg/L, P〈0.05）. The groups with high scores of job danger and job responsibility and burden had significantly higher salivary cortisol concentrations than those with low scores （80.29±9.45μg/L vs 75.60±16.41, P〈0.05; 80.94±10.87μg/L vs 74.05±16.35μg/L, P〈0.05）. The salivary cortisol concentration was positively correlated with the scores of job danger and job responsibility and burden （r=0.176 and 0.252, P〈0.05） and negatively correlated with the score of job control （r=-0.208, P〈0.05）. Conclusion Salivary cortisol concentration is positively correlated with occupational stress and increases with the increasing degree of occupational stress, and can be used as an objective biomarker for the identification and evaluation of occupational stress.

关 键 词：职业应激 氢化可的松 唾液 

分 类 号：R135[医药卫生—劳动卫生]