定量时间空间控制在生长因子促血管形成中的作用  

Function quantitative control of time and space in the growth factor to promote angiogenesis

作　　者：徐孟丹[1] 邹多宏[1] 

机构地区：[1]安徽医科大学口腔医学院,安徽医科大学附属口腔医院,安徽省口腔疾病研究中心实验室,合肥230032

出　　处：《国际口腔医学杂志》2016年第2期195-200,共6页International Journal of Stomatology

基　　金：国家自然科学基金(31370983);教育部科技研究重点项目(212080);安徽医科大学博士科研基金(XJ201109)~~

摘　　要：低血性疾病危害性大,致死、致残率高,已成为临床医学面临的难题之一,而血运重建对低血性疾病有明显疗效。血管发生和成熟需要多种血管生长因子在特定的时间空间和质量浓度下共同作用,正常的脉管系统需要血管内皮生长因子(VEGF)表达在时间和空间上的精确控制。在不同的时间和特定的微环境下,同一种生长因子的质量浓度亦不相同,也起着不同的作用,例如转化生长因子-β1、VEGF受体和低氧诱导因子等。在血管生成和组织功能重建过程中,血管新生的方向性受内皮细胞和平滑肌细胞定向迁移的影响,分支形态发生也受VEGF空间梯度的高度调节,体现出VEGF表达的空间分布特性。血管生长因子的时间空间控制需建立组织内细胞因子的定量标准,从而精确地控制损伤组织部位血管形成;寻找合适的传递系统,使组织内生长因子达到特定的部位。了解血管生长因子的时间、空间特性对新生血管的构建具有重要的作用,合理利用血管生长因子的这一特性,将为治疗血管性疾病提供更多的选择。Hemorrhagic disease which is harmfulness, high death rate and morbidity has become one of the challenges faced by the clinical medicine. While, the blood supply reconstruction of low hemorrhagic diseases have obvious curative effect. Angiogenesis need a variety of mature vascular growth factors in certain time space and mass concentration under the joint action of normal vasculature to vascular endothelial growth factor（VEGF） expression in precise control of time and space. Under different time the specific environment, mass concentration of the same kind of growth factor is not the same, which plays a different role, such as transforming growth factor-fll, VEGF receptors and hif, etc. In the process of angiogenesis and tissue function reconstruction, the direction of the angiogenesis under the influence of directional migration of endothelial cells and smooth muscle cells, branching morphogenesis and VEGF space gradient height adjustment, which reflects the space distribution features of VEGF expression. The time space of vascular growth factors control needs to establish the quantitative standards of cytokines in the organization, so as to accurately control formation damage tissue blood vessels; So looking for the right transfer system to achieve specific growth factors within the area, and understanding of time and space characteristics of vascular growth factor plavs an imnortant role in the construction of newblood vessels. The characteristics of the rational utilization of vascular growth factors will provide more choice for the treatment of vascular disease.

关 键 词：血管生长因子 基因增强的组织工程 血管生成 

分 类 号：R543[医药卫生—心血管疾病]