非编码RNA在卵泡发育和卵巢疾病中的研究进展  

Research progress of non-coding RNA in follicle development and ovarian diseases

作　　者：王静[1] 包日强 董麒铭 张春平[1] 

机构地区：[1]南昌大学,南昌330006

出　　处：《生殖与避孕》2016年第2期135-141,共7页Reproduction and Contraception

摘　　要：非编码RNA(non-coding RNA,nc RNA)是目前生物医学领域的研究热点,如长链非编码RNA(long non-coding RNA,lnc RNA)和小非编码RNA:微小RNA(mirco RNA,mi RNA)、内源性小干扰RNA(endogenous small interfering RNA,endo-si RNA)、PIWI相互作用RNA(PIWI interacting RNA,pi RNA)等,它们作为细胞内基因调控网络的重要成员影响细胞的各种生命活动。近年来研究表明这些非编码RNA在卵巢也发挥重要作用,参与了颗粒细胞增殖、分化、凋亡以及激素合成的调控,在卵母细胞存活和发育中发挥重要作用,非编码RNA的表达异常与多囊卵巢等疾病密切相关,本文就非编码RNA与卵巢卵泡发育以及卵巢相关疾病的研究作一简述。Non-coding RNA （ncRNA） has been the hotspot of biomedical field in recent years, such as long non-coding RNA （IncRNA）, mircoRNA （miRNA）, PIWI interacting RNA （piRNA） and endogenous small interfering RNA （endo-siRNA）. As important factors of gene regulating network, they play important roles in cellular activities. Recent studies showed that non-coding RNA was also involved in ovaries. In this paper, we will summarize the research progress of non-coding RNA in follicle development and ovarian diseases.

关 键 词：长链非编码RNA(lncRNA) 微小RNA(miRNA) PIWI相互作用RNA(piRNA) 内源性小干扰RNA(endo-siRNA) 卵泡发育 

分 类 号：R711.75[医药卫生—妇产科学]