全部胚胎冷冻保存在卵巢低反应患者微刺激方案IVF-ET中的应用  

Clinical application of all embryos cryopreservation for mild stimulation protocol IVF-ET in women with poor ovarian response

作　　者：张少娣[1,2] 李杭生[1,2] 张国玲[1,2] 张艳青[1,2] 张翠莲[1,2] 

机构地区：[1]河南省人民医院,郑州450000 [2]郑州大学人民医院,郑州450000

出　　处：《生殖与避孕》2016年第2期148-151,共4页Reproduction and Contraception

摘　　要：目的:探讨全部胚胎冷冻保存对卵巢低反应患者微刺激方案助孕结局的影响。方法:回顾性分析微刺激方案IVF-ET共483个周期,根据胚胎移植时机不同分为A组(新鲜胚胎移植组,275个周期)和B组[全部胚胎冷冻保存首次冷冻胚胎复苏移植术(FET)组,208个周期],比较组间患者的年龄、基础FSH、不孕年限、扳机日优势卵泡数目、内膜厚度、获卵数、可利用胚胎数及临床妊娠率、胚胎种植率、流产率。结果:A组扳机日内膜厚度和获卵数高于B组,差异有统计学意义(P<0.05),A组的临床妊娠率、胚胎种植率低于B组,差异有统计学意义(P<0.05),患者的年龄、基础FSH、Gn总量、扳机日优势卵泡数、扳机日雌二醇(E2)和孕酮(P)值、可利用胚胎数、移植周期内膜厚度、移植胚胎数、流产率组间均无统计学差异(P>0.05)。结论:对于使用微刺激方案助孕的卵巢低反应患者,全部胚胎冻存择期进行FET可以改善其助孕结局,是一种值得临床推广的助孕策略。Objective： To explore the clinical application of all embryos cryopreservation for mild stimulation protocol in vitro fertilization-embryo transfer （IVF-ET） in women with poor ovarian response （POR）. Methods： A total of 483 cycles of mild stimulation protocol for IVF-ET were retrospectively analyzed. According to the timing of embryo transfer, the patients were divided into group A （fresh embryo transfer, 275 cycles） and group B [the first frozen-thawed embryo transfer （FET） of all embryos cryopreservation, 208 cycles]. The age, basal FSH, duration of infertility, number of dominant follicles on trigger day, endometrial thickness, the number of retrieved oocytes, portable embryos number, clinical pregnancy rate, implantation rate and abortion rate were compared. Results： The endometrial thickness on trigger day and the number of retrieved oocytes in group A were higher than those in group B （P〈0.05）, the clinical pregnancy rate and the implantation rate in group A were significantly lower compared with group B （P〈0.05）. There were no significant differences between the two groups in age, basal FSH, the dose of gonadotropin, the number of dominant follicles on trigger day, E2 and P value on trigger day, portable embryos number, endometrial thickness in ET cycle, the number of ET embryo and the abortion rate （/9〉0.05）. Conclusion： The strategy of all embryos cryopreservation and selective FET could improve the clinical outcomes of POR patients with mild ovarian stimulation, it＇s a worthy strategy to promote in assisted reproductive technology.

关 键 词：全部胚胎冷冻保存 微刺激 卵巢低反应 临床妊娠率 胚胎种植率 

分 类 号：R714.8[医药卫生—妇产科学]