控制性超促排卵刺激中子宫内膜息肉对体外受精-胚胎移植妊娠结局的影响  

Influence of newly diagnosed endometrial polyps during controlled ovarian hyperstimulation on pregnancy outcome in in vitro fertilization-embyo transfer

作　　者：许思娟[1] 倪亚莉[1] 张红红[1] 安锦霞[1] 冯帆[1] 王琰[1] 杨杰[1] 贺清[1] 张霖[1] 王嘉羚[1] 

机构地区：[1]甘肃省妇幼保健院生殖医学中心,兰州730050

出　　处：《生殖与避孕》2016年第2期152-155,159,共5页Reproduction and Contraception

基　　金：甘肃省科技厅支撑计划项目(1104FKCA145)

摘　　要：目的:探讨在控制性超促排卵(controlled ovarian hyperstimulation,COH)刺激过程中新诊断的子宫内膜息肉(endometrial polyp,EP)对体外受精/卵胞质内单精子显微注射-胚胎移植(IVF/ICSI-ET)新鲜周期妊娠结局的影响。方法:选择行IVF/ICSI-ET新鲜周期的3 003例患者的3 003个周期进行回顾性分析。IVF/ICSI-ET术前行相关检查诊断宫腔形态正常,根据在COH过程中是否新发现EP将其分为研究组(新发现息肉,n=60)和对照组(未发现息肉,n=2 943)。观察患者妊娠结局。结果:患者的临床妊娠率、自然流产率、继续妊娠率组间比较,差异均无统计学意义(P>0.05)。研究组和对照组生化妊娠率(20.0%vs 9.8%)、异位妊娠率(3.3%vs 0.1%),差异有统计学意义(P=0.035,P<0.000 1)。结论:在COH刺激过程中新诊断的与生化妊娠和异位妊娠的发生相关,但不影响IVF-ET新鲜周期的最终临床妊娠率、继续妊娠率以及早期流产率的发生。Objective： To investigate the influence of newly diagnosed endometrial polyps （EP） during controlled ovarian hyperstimulation （COH） on the outcomes of fresh in vitro fertilization/intracytoplasmic sperm injection-embryo transfer （IVF/ICSI-ET） cycles. Methods： A total of 3 003 patients undergoing IVF/ICSI were studied, retrospectively. Patients were stratified into two groups based on the presence or absence of newly diagnosed EP during COH, which were divided into research group （n=60） and control group （n=2 943）. Results： There was no statistical difference in the overall clinical pregnancy rate, spontaneous miscarriage rate, and ongoing pregnancy rate between research group and control group （P〉0.05）. The biochemical pregnancy rate （20.0% vs 9.8%） and the ectopic pregnancy rate （3.3% vs 0.1%） were statistically different between the two groups （P=0.035, P〈0.000 1）. Conclusion： Newly diagnosed EP during COH is associated with an increased biochemical pregnancy rate and ectopic pregnancy rate, but does not adversely impact clinical pregnancy rate or ongoing pregnancy rate after fresh IVF-ET.

关 键 词：体外受精-胚胎移植(IVF-ET) 妊娠结局 宫腔镜 子宫内膜息肉(EP) 

分 类 号：R714.8[医药卫生—妇产科学]