轻度认知障碍磁共振扩散张量成像研究的Meta分析  

Measurement of diffusion tensor imaging in patients with mild cognitive impairment: a meta analysis

作　　者：王东东[1] 姜春晖[1] 王俭[1] 

机构地区：[1]新疆医科大学第一附属医院影像中心核磁室,乌鲁木齐830054

出　　处：《磁共振成像》2016年第2期81-89,共9页Chinese Journal of Magnetic Resonance Imaging

摘　　要：目的用Meta分析法评价磁共振扩散张量成像对轻度认知障碍(mild cognitive impairment,MCI)的诊断价值。材料与方法使用计算机检索数据库Pubmed、CNKI、万方、维普等,收集有关磁共振扩散张量成像对MCI研究的文献,检索时限均为自建库至2015年1月31日。从文献中提取轻度认知障碍组与正常对照组(NC)所使用的定量指标各向异性(fractional anisotrophy,FA)值对不同脑区(额叶、顶叶、颞叶、枕叶、后扣带束、海马、海马旁回、内囊后肢、上、下纵束、穹窿、胼胝体膝部及压部、钩束)的测量数据,用Meta分析软件(Review manager 5.3)对最终符合标准的文献进行汇总分析,获得汇总加权均数差(weighted mean difference,WMD)及95%可信区间(95%CI)。结果共纳入47篇文献(30篇英文、17篇中文),MCI组的FA值低于NC组,汇总WMD及95%CI为–0.05[–0.05,0.04],上述脑区除枕叶外差异均具有统计学意义。结论 MCI患者存在脑白质微细结构的损害,弥散张量成像(diffusion tensor imaging,DTI)技术能够提供MCI的早期诊断指标。Objective： To investigate the value of MR diffusion tensor imaging in diagnosis of mild cognitive impairment （MCI） with Meta-analysis. Materials and Methods： A search in computer databases such as PubMed, CNKI WanFang and VIP Data was performed, the relevant literature which are related to the MR diffusion tensor imaging in diagnosis of MCI were collected from the date of the above mentioned databases＇ establishment to January 31, 2015. The measured data of MCI and normal control （NC） was extracted from different brains （frontal lobe, parietal lobe, temporal lobe, occipital lobe, posterior cingulated fasciculus, hippocampus, parahippocampal gyms, posterior limb of the internal capsule, fasciculus longitudinal superior, fasciculus longitudinal inferior, fornix, genu of corpus callosum, splenium of corpus callosum, uncinatus fasciculus）, the relevant articles were analyzed with the Review Manager 5.3 to achieve weighted mean difference （WMD） with 95% confidence level CI. Results： Totally 47 articles including 30 English articles and 17 Chinese articles were collected. The outcome indicates the values of FA in the MCI group are lower than that in the NC group, and the WMD with 95% CI is -0.05[-0.05, 0.04], the values of FA of both the above metioned brains have significantly statistical difference except occipital lobe. Conclusion： The microstructural white matter in MCI group have been impaired, DTI can provide early diagnosis index of MCI.

关 键 词：轻度认知障碍 扩散张量成像 META分析 帕金森病 

分 类 号：R445.2[医药卫生—影像医学与核医学] R742[医药卫生—诊断学]