半夏泻心汤提取液对多重耐药性幽门螺杆菌的抑制作用  

Inhibitory effects of Banxia Xiexin Decoction Extracts on multidrug resistant Helicobacter pylori

作　　者：黄干荣[1] 莫小强[1] 黄衍强[1] 赵丽娟[1] 周滢龙 马豪[2] 吴红励 张琦[2] 韦柳兴 李小玲[2] 

机构地区：[1]右江民族医学院,广西百色533000 [2]右江民族医学院临床学院,广西百色533000

出　　处：《右江民族医学院学报》2016年第1期12-13,19,共3页Journal of Youjiang Medical University for Nationalities

基　　金：广西重点学科(病原生物学)([2013]16);广西重点实验室培育基地(桂教科研[2014]6);广西科学研究与技术开发计划项目(桂科能1598025-33);2013年广西高校科学技术研究项目(2013YB186);2015年广西高校科学技术研究项目(KY2015ZD091)

摘　　要：目的探讨半夏泻心汤对幽门螺杆菌多重耐药菌株(Hp MDR)的抑制作用。方法用二倍稀释法检测Hp MDR,制备半夏泻心汤提取液培养基,检测半夏泻心汤提取液对Hp MDR的最低抑菌浓度(MIC),并用黄连素和生理盐水分别作为阳性对照和阴性对照。结果筛选出2株Hp MDR,半夏泻心汤提取液对2株Hp MDR的MIC分别为6.25mg/ml、12.5mg/ml,黄连素的MIC均为12.5mg/ml。结论半夏泻心汤提取液对多重耐药性幽门螺杆菌有明显的抑制作用,其作用略优于黄连素。Objective To investigate the inhibitory effects of Banxia Xiexin Decoction Extracts on multi drug resistant Helicobacter pylori （MDR H. pylori）. Methods A double dilution method was used to iso late MDR H. pylori strains. Banxia Xiexin Decoction Extratcts culture media was prepared and the minimum inhibitory concentrations （MICs） of Banxia Xiexin Decoction Extratcts on MDR H. pylori strains were meas ured. Berberine and normal saline were used as positive control and negative control, respectively. Results Two MDR H. pylori strains were isolated. The MICs of Banxia Xiexin Decoction Extracts against two strains were 6.25mg/ml, 12.5 mg/ml, respectively, and both MICs of berberine were 12.5 mg/ml. Conclusion Banxia Xiexin Decoction Extracts have obvious inhibitory effects on MDR H. pylori strains, and its effective ness is slightly superior to berberine.

关 键 词：半夏泻心汤提取液 幽门螺杆菌多重耐药株 抑制 

分 类 号：R289.5[医药卫生—方剂学]