幽门螺杆菌根除治疗对幽门螺杆菌阳性的糖尿病胃轻瘫患者疗效及安全性的Meta分析  

Effectiveness and safety of Helicobacter pylori eradication in treating diabetic gastroparesis patients with Helicobacter pylori infection: Meta-analysis

作　　者：毕研贞[1] 乐亚朋 李锦[1] 方萧 左赛[2] 孔令斌[3] 

机构地区：[1]山东大学医学院,山东省济南市250100 [2]济宁医学院研究生处,山东省济宁市272013 [3]济宁医学院诊断学教研室,山东省济宁市272013

出　　处：《世界华人消化杂志》2016年第3期487-492,共6页World Chinese Journal of Digestology

摘　　要：目的:评价幽门螺杆菌(Helicobacter pylori,H.pylori)根除治疗对幽门螺杆菌阳性的糖尿病胃轻瘫(diabetic gastroparesis,DGP)患者的疗效及安全性.方法:计算机检索PubMed、EMbase、Cochrane Library、万方数据库、中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBMdice)等中英文数据库,收集采用H.pylori根除治疗和常规治疗来比较治疗H.pylori阳性的胃轻瘫患者的随机对照试验,利用Revman5.3软件对纳入资料进行Meta分析.结果:共纳入6篇符合标准文献,合计508例患者资料.Meta分析结果显示:同对照组相比,H.pylori根除治疗组在缓解糖尿病胃轻瘫方面存在优势(RR=1.33,95%CI:1.21-1.47,P<0.00001);治疗组与对照组的不良反应发生率无统计学差异(P=0.39).结论:与对照组相比H.pylori根除治疗组的临床疗效明显,可使糖尿病胃轻瘫患者的不适症状得到显著缓解,而且不会增加不良反应的发生率.AIM： To evaluate the effectiveness and safety of Helicobacter pylori（H. pylori） eradication in treating diabetic gastroparesis（DGP） patients with H. pylori infection.METHODS： Online databases（PubMed, EMbase, Cochrane Library, Wangfang, CNKI and CBMdice） were searched for randomized controlled trials investigating therapeutic effects of H. pylori eradication vs conventional treatment. Outcomes were analyzed with RevMan 5.3.RESULTS： Six randomized controlled trials containing 508 patients were included. The results of meta-analysis showed that H. pylori eradication was superior to conventional treatment for DGP patients in clinical effects（RR = 1.33, 95%CI： 1.21-1.47, P 0.00001）. The incidence of adverse events was similar between the two therapies（P = 0.39）.CONCLUSION： Compared with the conventional treatment, H. pylori eradication has moresignificant clinical effects and comparable incidence of adverse events.

关 键 词：幽门螺杆菌 根除治疗 糖尿病胃轻瘫 META分析 

分 类 号：R587.2[医药卫生—内分泌] R573[医药卫生—内科学]