A multi-channel analog IC for in vitro neural recording  

作　　者：袁丰 王志功 吕晓迎 

机构地区：[1]Institute of RF- & OE-ICs Southeast University [2]Co-innovation Center of Neuroregeneration Nantong University [3]State Key Laboratory of Bioelectronics Southeast University

出　　处：《Journal of Semiconductors》2016年第2期142-147,共6页半导体学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.61076118)

摘　　要：Recent work in the field ofneurophysiology has demonstrated that, by observing the firing characteristic of action potentials （AP） and the exchange pattern of signals between neurons, it is possible to reveal the nature of ＂memory＂ and ＂thinking＂ and help humans to understand how the brain works. To address these needs, we developed a prototype fully integrated circuit （IC） with micro-electrode array （MEA） for neural recording. In this scheme, the microelectrode array is composed by 64 detection electrodes and 2 reference electrodes. The proposed IC consists of 8 recording channels with an area of 5 x 5 mm2. Each channel can operate independently to process the neural signal by amplifying, filtering, etc. The chip is fabricated in 0.5-#m CMOS technology. The simulated and measured results show the system provides an effective device for recording feeble signal such as neural signals.Recent work in the field ofneurophysiology has demonstrated that, by observing the firing characteristic of action potentials （AP） and the exchange pattern of signals between neurons, it is possible to reveal the nature of ＂memory＂ and ＂thinking＂ and help humans to understand how the brain works. To address these needs, we developed a prototype fully integrated circuit （IC） with micro-electrode array （MEA） for neural recording. In this scheme, the microelectrode array is composed by 64 detection electrodes and 2 reference electrodes. The proposed IC consists of 8 recording channels with an area of 5 x 5 mm2. Each channel can operate independently to process the neural signal by amplifying, filtering, etc. The chip is fabricated in 0.5-#m CMOS technology. The simulated and measured results show the system provides an effective device for recording feeble signal such as neural signals.

关 键 词：analog integrated circuits neural signal recording neural signal amplifier micro-electrode arrays pseudo resistor 

分 类 号：R319[医药卫生—基础医学] TN409[电子电信—微电子学与固体电子学]