老年患者心脏手术后注射氟比洛芬酯与心房颤动相关性的回顾性研究  

Retrospective Study on the Correlation of Flurbiprofen Axetil Injection and Atrial Fibrillation in Elderly Patients after Cardiac Operation

作　　者：潘晓锋[1] 何林峰[1] 

机构地区：[1]台州市立医院心胸外科,浙江台州318000

出　　处：《中国药师》2016年第2期314-316,共3页China Pharmacist

摘　　要：目的:探讨老年患者心脏手术后注射氟比洛芬酯与发生心房颤动的相关性,分析作用机制。方法:采用回顾性研究方法,选取老年心脏手术患者62例的病历资料,按给药的不同分成试验组和对照组。心脏手术后,对照组使用芬太尼镇痛,试验组使用氟比洛芬酯镇痛。观察两组治疗前后血清C反应蛋白(CRP)水平变化、术后房颤发生率、术后房颤持续时间、住院时间、半年内心血管疾病发病率及药品不良反应。结果:给药后试验组血清CRP水平明显低于本组治疗前,以及对照组治疗后(P<0.05或P<0.01)。试验组术后房颤发生率、房颤持续时间均明显低于对照组(P<0.05)。两组患者术后住院时间、半年内心血管疾病发病率比较,差异无统计学意义(P>0.05)。两组药品不良反应发生率差异无统计学意义(P>0.05)。结论:心脏手术后注射氟比洛芬酯心房颤动发生率明显低于芬太尼。Objective： To investigate the relationship between flurbiprofen axetil injection and atrial fibrillation in the elderly patients after cardiac surgery and underlying mechanism. Methods： A retrospective research method was applied, and the medical records of 62 elderly patients with cardiac surgery were chosen and divided into the experimental group and the control group according to the different medication. After the heart surgery, fentanyl was used in the control group, and flurbiprofen was applied in the experimental group. Before and after the treatment, the serum C-reactive protein levels, the incidence of postoperative atrial fibrillation, postoperative atrial fibrillation duration, length of stay, incidence of cardiovascular disease in 6 months and adverse reactions were observed and compared between the two groups. Results： After the treatment, the serum CRP levels in the experimental group were significantly lower than those before the treatment and those in the control group after the treatment （P 〈 0.05 or P 〈 0.01 ）. The incidence of post- operative atrial fibrillation in the experimental group was significantly lower than that in the control group （P 〈 0.05）. The duration of postoperative atrial fibrillation in the experimental group was significantly shorter than that in the control group （P 〈 0.05 ）. The differences in the postoperative hospital stay, the incidence of cardiovascular disease in six months and the incidence of adverse reactions were not statistically significant between the two groups （ P 〉 0.05 ）. Conclusion： Flurbiprofen axetil injection used after cardiac surgery can reduce the incidence of atrial fibrillation, which shows important clinical significance.

关 键 词：心脏手术 氟比洛芬酯 心房颤动 芬太尼 回顾性研究 

分 类 号：R971.1[医药卫生—药品]