非诺贝特在糖尿病性黄斑水肿中的临床研究  

Clinical study of fenofibrate in diabetic macular edema

作　　者：陈素芳[1] 李亨辉[2] 邵毅[1] 曾莉[1] 黎明明[1] 高桂平[1] 

机构地区：[1]南昌大学第一附属医院眼科,江西省南昌市330006 [2]吉安市中心人民医院眼科,江西省吉安市330000

出　　处：《眼科新进展》2016年第2期136-138,142,共4页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号:81160118;81400372);全国临床医药研究专项基金(编号:L2012052);江西省远航工程(编号:2014022);江西省学位与研究生教育教学改革研究项目(编号:2015);江西省科技平台建设项目(编号:2013116);江西省青年科学基金(编号:20151BAB215016);江西省科技支撑计划项目(编号:20151BBG70223);江西省教育厅科技计划项目(编号:GJJ14170);江西省卫计委科技计划项目(编号:20155154);赣江学者计划(2015)~~

摘　　要：目的观察非诺贝特在视网膜光凝后糖尿病性黄斑水肿(diabetic macular edema,DME)中的疗效。方法观察38例(67眼)已完成视网膜光凝的DME患者,其中15例(23眼)为增生型糖尿病性视网膜病变,23例(44眼)为非增生型糖尿病性视网膜病变;随机分为两组,其中A组20例(35眼)口服非诺贝特+复方血栓通胶囊,B组18例(32眼)单独口服复方血栓通胶囊,两组均连续服药28 d,28 d后采用光学相干断层扫描随诊观察两组黄斑中心凹视网膜平均厚度(average foveal retinal thickness,AFRT)、平均黄斑容积(average macular volume,AMV)、黄斑区视网膜平均厚度(average macular thickness,AMT),并观察两组视力情况。结果用药28 d后,在视力改善方面A组优于B组,差异有统计学意义(P<0.05);A组AFRT、AMV、AMT均较用药前明显减少,差异均有统计学意义(均为P<0.05);B组AFRT、AMV、AMT均较用药前稍有增加,差异均有统计学意义(均为P<0.05);A组患者用药后黄斑水肿消退各指标(AFRT、AMV、AMT)较B组明显减少,差异均有统计学意义(均为P<0.05)。结论非诺贝特能改善DME患者视力,有效促进视网膜光凝后黄斑水肿的吸收。Objective To investigate the efficacy of fenofibrate in dia- betic macular edema （DME） after retinal photocoagulation. Methods The randomized controlled study included 38 DME patients （67 eyes） who comple- ted retinal photocoagulation, including 15 patients （23 eyes） of proliferative diabetic retinopathy （PDR） and 23 patients （44 eyes） of non-proliferation dia- betic retinopathy （NPDR）. Patients were randomized into two groups： fenofi- brate and Xueshuangtong capsule administered to group A （20 cases,35 eyes） and only Xueshuangtong capsule administered to group B （ 18 cases,32 eyes） for 28 days. After 28 days, the average foveal retinal thickness （ AFRT）, aver- age macular volume （ AMV）, average macular thickness （AMT） were observed by optical coherence tomography, and the corrected visual acuity was also ob- served. Results After 28d treatment, group A achieved better visual acuity than group B, the difference was statistically significant （ P 〈 0. 05 ） ; In the group A, AFRT, AMV, AMT were less than before treatment, the difference was statistically significant（ all P 〈 0.05 ） ; In the group B, AFRT, AMV, AMT were more than before treatment, the difference was statistically significant （ all P 〈 0.05 ）. After 28d treatment,there were significantly difference in AFRT, AMV, AMT between two groups （ all P 〈 0.05 ）. Conclusion Fenofibrate can im- prove visual acuity and effectively promote the absorption of DME after retinal photocoagulation.

关 键 词：非诺贝特 糖尿病性黄斑水肿 光学相干断层扫描 

分 类 号：R587.2[医药卫生—内分泌]