糖尿病视网膜病变易感基因的研究进展  

Recent advances in susceptibility genes of diabetic retinopathy

作　　者：樊维[1,2] 谢琳[1] 

机构地区：[1]南昌大学第二附属医院,江西省南昌市330000 [2]南昌大学,江西省南昌市330000

出　　处：《眼科新进展》2016年第2期190-193,共4页Recent Advances in Ophthalmology

基　　金：国家自然科学基金(编号:81160123);江西省科技支撑计划(重点项目)(编号:2010BSA15800);江西省自然科学基金(编号:2010GQY0269)~~

摘　　要：糖尿病视网膜病变(diabetic retinopathy,DR)是糖尿病常见以及严重的微血管并发症,是导致视力不可逆性丧失的重要原因之一。DR发生发展受多种因素影响,其发病机制一直是研究热点。一直以来,糖尿病病程被认为是DR发生发展的重要因素,但是在临床上,糖尿病病程长未发DR者以及糖尿病病程短而DR进展迅速者并不少见。近年来不断有研究提示基因对糖尿病发病机制有着至关重要的影响,本文就几个与DR发病有关的重要的易感基因研究进展作一综述。Diabetic retinopathy （DR） is a kind of frequent and serious microvascu- lar complication of diabetes ,which is one of the important reasons resulting in the irre- versible loss of vision. The occurrence and development of DR are influenced by many factors, its pathogenesis is always the hot topic. All the time, the duration of diabetes is considered as the important factor of DR, but in fact, long duration of diabetes without DR and short duration of diabetes with serious DR are not uncommon. Recent years, many researches show gene is of much importance to the pathogenesis of DR. This arti- cle reviews the recent advances in several susceptibility genes linked with DR.

关 键 词：糖尿病视网膜病变 发病机制 易感基因 

分 类 号：R587.2[医药卫生—内分泌]