不同胎龄新生儿骨代谢血清标志物及IGF-I检测  

The Test and Clinic Significance of Bone Metabolism Biochemical Markers and IGF-I in Newborn with Different Gestational Age

作　　者：孙瑞[1] 王鉴 

机构地区：[1]贵州医科大学附院新生儿科,贵州贵阳550004

出　　处：《贵阳医学院学报》2016年第2期170-174,共5页Journal of Guiyang Medical College

基　　金：贵州省科技厅科学技术基金[黔科合J字(2009)2160号]

摘　　要：目的:探讨不同胎龄新生儿出生后1 h、7 d及3月时的骨生化代谢标志物及胰岛素样生长因子-1(IGF-1)的变化及趋势。方法:早产儿及足月儿共125例,根据胎龄分为早期早产儿组32例、晚期早产儿组46例及足月儿组47例,分别于生后1 h、7 d及3月时抽取空腹静脉血4 m L,检测血清钙(Ca)、磷(P)、维生素D3(Vit D3)、骨源性碱性磷酸酶(BAP)及IGF-1。结果:3组新生儿血清Vit D3、Ca水平,随胎龄及日龄增加而升高,差异有统计学意义(P<0.05);2组早产儿血清IGF-1水平随胎龄、日龄增加而升高,差异有统计学意义(P<0.05);各年龄段3组新生儿血清BAP水平差异有统计学意义(P<0.05),随日龄增加,晚期早产儿组及足月儿组BAP水平差异有统计学意义(P<0.05);随日龄增加,3组新生儿血清P水平差异有统计学意义(P<0.05);出生后3月时各组新生儿Vit D3、Ca、IGF-1水平达到正常值。结论:早产及足月产新生儿血清Vit D3及血清Ca水平随胎龄及日龄增加而升高,早产儿血清IGF-1水平随出生后日龄增加而升高;出生后3月时早产和足月产新生儿血清Vit D3、Ca及IGF-1水平达到正常值。Objective： To investigate the change and trend of biochemical markers of bone metabolism and insulin-like growth factor 1 （ IGF-1 ） 1 h, 7 d and 3 months after neonatal birth. Methods： A total of 125 cases of preterm infants and full-term infants were enrolled in this study. According to different gestational ages, they were divided into early preterm infants group （32 cases）, late preterm infants group （46 cases）, full-term group （47 cases）. For each infant, 4 ml fasting blood samples were collected respectively at 1 st hour, 7th day and 3 months after birth, then the serum levels of calcium （ Ca）, phosphorus （ P）, vitamin D3 （ VitD3 ）, bone alkaline phosphatase （BAP） and IGF-1 were detected. Results： The serum VitD3 , Ca levels days of neonatal infants, the differences were in three groups increased with gestational age and age in statistically significant （ P 〈 0.05 ）. The serum IGF-I levels increased with gestational age and age in days of neonatal infants in the two premature groups, the differences weres statistically significant （P 〈 0.05 ）. In the three groups of neonatal infants, the serum BAP levelg differences in all ages were statistically significant（P 〈0.05 ）. With the increasing of age in days, the differences of BAP levels between late preterm infants and full term group were sta- tistically significant （P 〈0.05 ）. With the increasing of age in days, neonatal serum P level＇s differences between three groups were statistically significant （ P 〈 0.05 ）. VitD3 , Ca and IGF-I levels of preterm infants and full-term infants returned to normal 3 months after birth. Conclusion： The serum VitD3 , Ca levels increase with gestational age and age in days of neonatal infants. For preterm infants,the serum IGF-I levels increase with gestational age and age in days of neonatal infants. VitD3 , Ca and IGF-I levels of preterm infants and full-term infants returned to normal 3 months after birth.

关 键 词：新生儿 骨发育 维生素D3 胰岛素样生长因子-1 钙 磷 

分 类 号：R725.895[医药卫生—儿科]