2008-2014年某医院鲍曼不动杆菌的临床分布与耐药性变迁  

Clinical Distribution and Drug Resistance Change of Acinetobactor baumannii in A Hospital from 2008 to 2014

作　　者：韩洁[1] 刘宝[2] 万珊[2] 杨焕婕[2] 费樱[2] 

机构地区：[1]贵州医科大学,贵州贵阳550004 [2]贵州医科大学附院微生物免疫科,贵州贵阳550004

出　　处：《贵阳医学院学报》2016年第2期197-201,共5页Journal of Guiyang Medical College

基　　金：贵州省科技厅基金资助项目[黔科合SY字(2012)3147]

摘　　要：目的:了解贵阳市某三甲医院鲍曼不动杆菌的临床科室分布及耐药性的变迁。方法:对2008-2014年贵阳市某三甲医院临床送检标本进行细菌鉴定和药敏试验,分析鲍曼不动杆菌检出率、主要标本来源、科室分布及对临床常用抗菌药物的耐药情况。结果:7年内共检出3 463株鲍曼不动杆菌,以分泌物中鲍曼不动杆菌的检出率最高,占12.15%;鲍曼不动杆菌的科室分布以重症监护室(ICU)和外科为主,分别占44.42%和33.15%;药敏结果显示,鲍曼不动杆菌对各类抗生素的耐药率表现为逐年升高,对亚胺培南、左氧氟沙星和替卡西林-克拉维酸耐药性升高最为明显。结论:鲍曼不动杆菌的临床检出率较高,该细菌耐药率呈逐年增加趋势,特别是对碳青霉烯类药物有较高耐药率。Objective： To investigate the clinical department distribution and drug resistance change of A. baumanii isolated from Jan 2008 to Dee 2014. Methods： The Microscan walkaway 40SI was used for identifying bacteria and drug susceptibility testing. Detection rates of A. baumanii, main specimen source, distribution of clinical department and drug resistance were analyzed. Results： A total of 3 463 clinical strains of A. baumanii were isolated during seven years. Detection rate of A. baumanii in the secretion was 12.15%, which is the highest during all specimens. A. baumanii strains was mainly distributed in ICU and surgery, accounting for 44.2% and 33.15%, respectively. The results of drug sensitive test showed that the rate of antibiotic resistance increased steadily year by year, especially obvious in resistance to imipenem, levofloxacin and ticarcillin/clavulanic acid. Conclusion： The clinical detection rate of A. baumanii is high. Drug resistance rates of A. baumanii to antibiotics increase year by year, especially to earbapenemase antibiotics.

关 键 词：鲍曼不动杆菌 感染 统计学分布 耐药性 抗生素类 

分 类 号：R446.62[医药卫生—诊断学]