异氟烷对中青年女性手术患者压力感受器反射敏感性的影响  

The Effects of Isoflurane on Baroreflex Sensitivity in Patients Undergoing Umbar Spine or Lower Extremity Orthopedic Surgery

作　　者：李萍[1] 谭明祥[2] 

机构地区：[1]贵阳市妇幼保健院儿童医院麻醉科,贵州贵阳550003 [2]贵州医科大学附院麻醉科,贵州贵阳550004

出　　处：《贵阳医学院学报》2016年第2期219-221,共3页Journal of Guiyang Medical College

摘　　要：目的:探讨异氟烷对中青年女性手术患者压力感受器反射敏感性的影响。方法:将择期行腰椎或下肢骨科手术的女性患者24例,随机分为对照组(不吸入异氟烷)、异氟烷0.7最低肺泡有效浓度(MAC)组、1.0 MAC组及1.3 MAC组,分别于麻醉诱导前、诱导后及达到预定MAC平稳时测定手术患者的心率(HR)、收缩压(SBP)以及平均动脉压(MAP),并计算压力反射敏感性(BRS)。结果:与对照组比较,异氟烷组HR增快(P<0.05),SBP、MAP降低(P<0.05);与0.7 MAC组比较,1.0 MAC组及1.3 MAC组SBP、MAP显著降低(P<0.05);与1.0 MAC组比较,1.3 MAC组SBP、MAP显著降低(P<0.05);与对照组比较,0.7 MAC组BRS差异无统计学意义(P>0.05),1.0 MAC组及1.3 MAC组BRS显著降低(P<0.05);与1.0 MAC组比较,1.3 MAC组的BRS值降低(P<0.05)。结论:异氟烷能抑制压力感受器反射敏感性,其对心率的影响与BRS受抑制有关。Objective： To investigate the effects of isoflurane on baroreceptor reflex sensitivity of young and middle aged female surgical patients. Methods： Twenty-four cases of female patients undergoing lumbar or lower extremity orthopedics operation were randomly divided into 4 groups （n = 6 ） ： control group （no isoflurane） , 0.7 MAC group, 1.0 MAC isoflurane group and 1.3 MAC isoflurane group. HR, SBP, and MAP were determined before anesthesia induction （ Tl ） , after induction of an- esthesia and reaching a predetermined MAC smooth （T2 ） , and BRS （baroreflex sensitivity） was calculated. Results： Compared with control group, HR significantly increased and SBP, MAP decreased in isoflurane groups （P 〈 0. 05 ）. Compared with 0.7 MAC group, the SBP and MAP of 1.0 MAC group and 1.3 MAC group significantly decreased （P 〈 0.05）. Compared with 1.0 MAC group, the SBP, MAP of 1.3 MAC group significantly decreased （P 〈 0. 05 ）. There was no statistical difference of BRS between control group and 0.7 MAC group （P 〉 0.05 ） but compared with control group, the BRS of 1.0 MAC group and 1.3 MAC group significantly decreased（P 〈 0.05）. Compared with 1.0 MAC group, the BRS of 1.3 MAC group significantly decreased （P 〈 0.05 ） Conclusion： Isoflurane can inhibit the BRS, which may be related to its effect on HR.

关 键 词：异氟烷 血压 心率 压力感受器反射 

分 类 号：R614[医药卫生—麻醉学]