135例药品不良反应报告分析  

Analysis of 135 cases of adverse drug reaction reports

作　　者：白万军[1] 邱志宏[1] 孙晓利[2] 赫立恩[1] 安静[1] 马杰[1] 董占军[1] 

机构地区：[1]河北省人民医院药学部,河北石家庄050051 [2]河北医科大学第四医院药学部,河北石家庄050011

出　　处：《中国药物应用与监测》2016年第1期40-43,共4页Chinese Journal of Drug Application and Monitoring

摘　　要：目的:了解我院药品不良反应发生的特征,为临床安全合理用药提供参考。方法:采用回顾性调查方法,收集我院2013–2014年上报的135例药品不良反应报表,按照患者的性别、年龄、ADR报告分级、给药途径、药品种类、累及的系统/器官及临床转归等情况进行统计分析。结果:老年人是ADR的高发人群;大多数ADR是通过静脉给药方式引起的。在涉及药品不良反应的14个药品类别中,生物/生化药品位列首位(19.51%),其次为抗菌药物(17.68%)。ADR累及的系统/器官主要为全身性损害(31.84%),其次是皮肤及其附件损害(26.46%)。结论:引发ADR的药品种类呈现新的变化趋势,生物/生化药品的不良反应应引起高度关注。临床工作中应加强ADR的监测,确保临床药物治疗安全、有效。Objective： To investigate the characteristics of adverse drug reactions （ADRs） in our hospital, and provide references for rational drug use in clinic. Methods： There were 135 ADR cases collected in our hospital from 2013 to 2014, which were retrospectively analyzed in respect of gender, age, classification of ADRs reports, routes of administration, categories of drugs, systems and organs involved in ADRs, the clinical outcomes and so on. Results： The elderly were high-risk population occurred ADRs. Intravenous administration was the main route of administration that led to ADRs. Among 14 drug categories of ADRs, the first was biological/biochemical drugs （19.51%）, followed by antimicrobials （17.68%）. Primary system/organ involved in ADRs was systemic damage （31.84%）, followed by skin and its appendages damage （26.46%）. Conclusion： The types of adverse drug reactions presents new trends and adverse reactions of the biological/biochemical drugs should be paid more attention to. The clinical monitoring and therapy of ADRs should be strengthened to ensure the safety and effectiveness of clinical drug therapy.

关 键 词：药品不良反应 生化药品 中药 合理用药 回顾性分析 

分 类 号：R969.3[医药卫生—药理学]