质子泵抑制剂致痛风复发2例  

Two cases of gout recurrence caused by proton pump inhibitor

作　　者：李媛[1] 高玉强[1] 姜志 曲海霞[1] 张巍巍[1] 马晓莹[1] 战淑慧[1] 

机构地区：[1]青岛市市立医院消化科,山东青岛266071 [2]青岛市中心血站献血服务科,山东青岛266000

出　　处：《中国药物应用与监测》2016年第1期63-64,共2页Chinese Journal of Drug Application and Monitoring

摘　　要：病例1:患者,男性,48岁,因黑便、呕血入院。入院后查血常规:WBC 8.6×109·L^(-1),HGB 78 g·L^(-1),PLT124×109·L^(-1)。尿酸562μmol·L^(-1)。胃镜:十二指肠球部溃疡。应用埃索美拉唑抑制胃酸分泌,用药2 d后出现双足关节红肿热痛,即刻停药,肌肉注射倍他米松后关节疼痛缓解。病例2:患者,男性,50岁,因"反复上腹痛1个月"入院。入院后行胃镜检查:胃窦溃疡。给予兰索拉唑30 mg,bid,ivgtt。入院5 d后突然出现双侧腕关节疼痛,查尿酸825μmol·L^(-1)。考虑为痛风,给予停用兰索拉唑,口服秋水仙碱片及碳酸氢钠片,外用双氯芬酸二乙胺乳胶剂,2 d后疼痛缓解。Case 1： one 48-year-old male patient with melena and haematemesis was admitted to hospital. The results of laboratory examinations were as follows： WBC 8.6 ×10^9·L^-1, HGB 78 g·L^-1, PLT 124 ×10^9·L^-1, uric acid 562μmol·L^-1. The result of gastroscope suggested duodenal bulbar ulcer. Esomeprazole was given to the patient. Two days later, joints of feet became red, swollen, pain and hot. Esomeprazole was stopped immediately, betamethasone was given to the patient by intramuscular injection and the pain relieved. Case 2： one 50-year-old male patient was admitted to hospital because of abdominal pain. The result of gastroscope suggested gastric antrum ulcer. Lansoprazole （30 mg, bid, ivgtt） was given to the patient. Five days later, bilateral wrist of the patient became red, swollen, pain and hot. Laboratory findings showed that uric acid was 825 μmol·L^-1.Clinical diagnosis was gout recurrence. Lansoprazole was stopped, while colchicines, soda mint and diclofenac diethylamine emulRel were given. The pain relieved after 2 days.

关 键 词：质子泵抑制剂 痛风 药品不良反应 

分 类 号：R589.7[医药卫生—内分泌]